Oral Controlled Release Drug Delivery Systems1, 2: Oral controlled release drug delivery is a drug delivery system that provides*give the continuous oral delivery of drugs at predictable and reproducible kinetics for a predetermined period throughout the course of GI transit and also the system that target the delivery of a drug to a specific region within the GI tract for either local or systemic action. All the pharmaceutical products formulated for systemic delivery via*throw the oral route of administration, irrespective of the mode of delivery (immediate, sustained or controlled release) and the design of dosage form (solid dispersion or liquid), must*should be developed within the intrinsic characteristics of GI physiology. …show more content…
That are unstable*degradable in the intestinal or colonic environment, iv. Have low solubility at high*higher pH values.
Gastro retentive Dosage Form (GRDF) 5, 6: It is evident*clear-cut from the recent scientific and patient literature that an increased interest in novel dosage forms that are retained in stomach for a prolonged and predictable period of time exists today in academic and industrial research groups. One of the most feasible approaches for achieving*attain a prolonged and predictable drug delivery in the GI tract is to control the gastric residence time (GRT), i.e. gastro retentive dosage form (GRDFs or GRDS). GRDFs extend*prolong significantly the period of time over which the drugs may be released. They not only prolong*longer dosing intervals, but also increase patient compliance beyond the level of existing controlled release dosage form.
Dosage form with prolonged GRT*gestro retentive time, i.e. gastro retention dosage form (GRDF), will bring about new and important therapeutic options such as*for example …show more content…
I) Fundus ii) Body and iii) Pylorus (or antrum).
The proximal stomach consisted*include of fundus and body, which serves as a reservoir for ingested materials, whereas the distal region (pylorus) is the major site of mixing motions, acting as a pump to propel gastric contents for gastric emptying. Gastric emptying occurs both *condition in fasting as well as fed states.
The GI*gastro intestinal tract is always in a state of continuous motility. There are *this have two modes of motility pattern. The*One is digestive mode and*another is interdigestive mode. In case of fasted state an interdigestive series of electrical events occurs*take place in cyclic manner both through stomach and small intestine every 2-3 hr. This electrical activity is termed as interdigestive my electric cycle.
Phase I : Period of no contraction.
Phase II : Period of intermittent contraction.
Phase III Phase IV :
: Period of regular contractions at the maximal frequency that migrate distally.
Is the transition period of 0-5 mins between Phase III &