Lignocaine is a widely used local anaesthetic. This drug shows inhibition of peristalsis due to its ability to block sodium ion protein channels in the nerves of the body. This prevents the initiation and rapid increase of nerve action potentials, this allows for its use as a local anaesthetic by acting on nociceptive neurons (Dale et al., 2015). This will then result in diminished amplitudes of contractions and indicates that only partial inhibition was occurring. …show more content…
Both of these drugs are antagonists. Atropine has an antagonising effect on the muscarinic acetylcholine receptors caused prevention of acetylcholine (Ach) release from excitatory motor neurons (Dale et al., 2015). Hexamethonium on the other hand is a nicotinic cholinergic antagonist. It is also often referred to as a prototypical ganglionic blocker. Finally we had Nicardipine. Nicardipine is a calcium entry blocker, also known as a calcium ion antagonist. It inhibits the calcium channels from providing the necessary calcium to the smooth muscle for contraction. It does this by inhibiting the muscle contractibility. By doing so, this inhibits