During Susan’s time, the OT found out what Susan can do versus what she is unable to do. The OT is trying to help Susan maintain and preserve her performance abilities that she had previously. Susan is a homemaker and is very precise with her home. The OT can do this by providing ongoing services to ensure she keeps her current occupational performance. Susan can take care of her personal hygiene, toileting, cleaning, and functional mobility.…
ABSTRACT Working with infectious agents that require BSL-3 level containment agents offers many challenges for researchers. BSL-3 containment laboratories are usually not equipped with expensive specialty equipment that is needed for studies such as flow cytometric analysis, microscopy, and proteomic analyses. Therefore, for most researchers that are working with BSL-3 level infectious agents, removal of samples from BSL-3 labs for these types of studies is necessary, and methods for complete and dependable inactivation of the samples are required. In this report we have done a thorough characterization of the effectiveness of paraformaldehyde fixation for inactivation of cell samples infected with the intracellular bacterial agents Burkholderia pseudomallei (Bp) and Francisella tularensis (Ft), both of which are Tier 1 select agent pathogens that require BSL-3 containment. We have demonstrated that cells infected with these pathogens are completely inactivated via 5-minute treatment with 4% paraformaldehyde.…
This drug only has moderate to very weak actions toward reverse signaling, CDC, and ADCC. The last drug, Certilizumab, only has strong binding affinity toward the two TNF ligands. The drug has very strong actions toward cytokine suppression, however very weak actions toward apoptosis, CDC, and ADCC.…
Gary, This project number is no longer active. It was closed last week. People charge their time to a suspense code last week. I’m assuming we overran the budget. Our original estimate didn’t take into consideration the iterative process of negotiating the final price.…
NOTCH2 and FLT3 may used as biomarkers in treatments like FISH and PCR. Rothe K., Lin H., et al. The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells. Blood 123(23), 3622-34(2014). PMID 24755409 Current treatment of Imatinib mesylate (IM) triggers autophagy in CML.…
According to the American Pharmacists Association, as of late July, Alirocumab, a PCSK9 inhibitor, obtained FDA approval. In addition to diet and aggressive statin therapy, Alirocumab acts as an aid for patients that have clinical atherosclerotic cardiovascular disease or heterozygous familial hypercholesterolemia. These patients are required to lower their cholesterol further. Alirocumab, a monoclonal antibody which is self-administered through subcutaneious injection every two weeks, lowers cholesterol by inhibiting PCSK9, whose primary purpose in the body is to reduce the receptors in the liver that dispose of LDL from the bloodstream. LDL is low-density lipoproteins that are considered “bad’ protein because they can collect on the walls of blood vessels, which, if untreated, can cause blockages.…
FLT3 mutations lead to constitutive activate of the FLT3 receptor through phosphorylation of the receptor. Internal tandem duplication (ITD) mutations of FLT3 are when 3-400 base pairs in the gene are duplicated. This mutation causes the FLT3 receptor to be constitutively activated (always activated/turned on). The way that the mutation activates the receptor is by causing it to be phosphorylated. When ligands bind to the FLT3 receptor, proliferative signaling pathways are activated, causing the cancer cell to survive and proliferate.…
I just got off the phone w/Jay from BCBS. According to him in order for their system to bypass the need for additional documentation for ultrasounds that exceed the max. # of 3 due to high risk Modifier KX should be added to the procedure code. He stated that this is certainly the rule for BCBS of MI.…
CSSHQ WALKWAY/PATIO REPAIR PROJECT. Ongoing concrete repairs prohibit exiting the building through the north doors and classroom. The length of the project will be determined by the weather. Please use additional caution when approaching or exiting until all repairs are complete. BE SAFE!…
Because the experiment takes place in a laboratory, Baumrind argues that participants will not act how they might in the real world. She states that the laboratory is an unaccustomed setting for a typical being and may cause anxiety and passivity (225). Correspondingly, Saul Mcleod, a psychologist who summarizes and critiques Milgram’s experiment, states that the “important” location of the experiment, obedience levels increased (Simply Psychology). The point about setting is one in which Baumrind and Parker are able to reach a consensus.…
HP has agreed to the following in regards to CIR's BLUF, it is essential that when the below information is not included in the CIRs the BWC or designate representative from the watch reach out to the Command Center to update the CIR with required information. i.e. affected CCSD , potential Impact to USMC, potentially impact to HIT sites (WIP). Also if it is a high level DISA outage the watch should reach to the DISA Command Center and obtain the CCSD from the DISA TT# provided by HP. By ensuring HP provide this information we will be better able to communicate and assess the impact to the COC and keep the lines of communication open with DISA…
Anti-TNF therapeutics are widely used in the treatment of both RA and CD and in many cases their…
However, in most scenarios, the target is based on the expression or overexpression of a certain protein. Most on the market treatment such as drugs that target BRAF or HER-2 are unable to treat all but a extremely specific form of cancer (American Cancer Society). Targeted treatment methods are currently the focus of many research efforts, and many preclinical trials are underway. It is the objective of this project to develop a more generalized targeted treatment…
Research is the key foundation of learning as well as a stimulant of the mind; it causes people to further investigate a subject that they are interested in and to develop various viewpoints on the subject. However research comes at a price, not only in the form of hard work, stress, and mental strain, but also in the form that most often eludes research from being done, the monetary form. In the medical world, research is fundamental to further not only the ability to diagnose, to treat diseases and disorders, but also to prevent them from reoccurring in subsequent generations. This lack of funding is seen specifically with Leukemia research, and is affecting progress towards a cure by delaying treatment, creating more difficult diagnoses,…
I was keenly aware of the importance of Genetics in health care early in my time studying Medicine and later have gained profound knowledge of it as well as Cell Biology and Molecular Biology through in-depth Biomedical studies. However, it is during my current study on the genetic disorder Neurofibromatosis type 1 (NF1) when my passion for the Laboratory Genetics and Genomics was lighted. My passion for the Laboratory Genetics and Genomics was lighted while I am conducting current studies on the genetic disorder Neurofibromatosis type 1 (NF1). However, it has long been deeply rooted since I was keenly aware of the importance of Genetics in health care early in my time studying Medicine and have gained profound knowledge of it as well as Cell…