More relevant to the function of CRP is human secretory phospholipase A2 with CRP may serve to promote phagocytosis of injured cells and tissue debris, an enzyme secreted by liver as an acute phase protein …show more content…
CRP recognition of phosphocholine on microorganisms which is play a key role in our protection against, a more significant role perhaps the binding CRP to PC in the injured membranes (Li et al., 1994).
The interaction of human CRP with cell wall polysaccharide (CWPS) has possibility to activate the classical complement pathway through interaction with C1q component, an activity which cannot be achieved via simple PC-bound (Volanakis, 1982). Binding of CRP to sugar phosphate is suggested to bind to occur via the carbohydrate component of the ligand in the area neighboring to the choline site, this area is as well proposed to bind glycerol of PC glycerol, both occurring by the OH group closest the phosphate (Lee et al.,