Creon is a member of a type of therapy called pancreatic enzyme replacement therapy1. Therefore, does not cure Exocrine Pancreatic Insufficiency but treats the symptoms of the disease. Pancreatic enzyme replacement therapy is basically where the patient will take the enzymes that are needed for digestion orally, in some sort of tablet or capsule3. Creon is administered in the form of an enteric-coated, delayed-release capsule2. The enteric-coating is meant to diminish destruction or inactivation from the acids in the stomach and gastrointestinal tract2. It is made up of a combination of porcine-derived enzymes, particularly, porcine-derived lipases, proteases, and amylases taken from a pig pancreas2. Once ingested, Creon, breaks food down in multiple ways depending on the type of food it is. Regarding fats and glycerols, Creon will catalyze the hydrolysis of the fat into monoglyceride and the glycerols into free fatty acids2. Creon will also catalyze the hydrolysis of proteins into peptides and amino acids2. Finally, Creon will take any starches and will do the same thing; catalyze the hydrolysis of the starch into dextrins and other short-chain sugars2. All of the catalyzation of these molecules takes place in the duodenum and proximal small intestine, simulating the digestive enzymes that would be physiologically
Creon is a member of a type of therapy called pancreatic enzyme replacement therapy1. Therefore, does not cure Exocrine Pancreatic Insufficiency but treats the symptoms of the disease. Pancreatic enzyme replacement therapy is basically where the patient will take the enzymes that are needed for digestion orally, in some sort of tablet or capsule3. Creon is administered in the form of an enteric-coated, delayed-release capsule2. The enteric-coating is meant to diminish destruction or inactivation from the acids in the stomach and gastrointestinal tract2. It is made up of a combination of porcine-derived enzymes, particularly, porcine-derived lipases, proteases, and amylases taken from a pig pancreas2. Once ingested, Creon, breaks food down in multiple ways depending on the type of food it is. Regarding fats and glycerols, Creon will catalyze the hydrolysis of the fat into monoglyceride and the glycerols into free fatty acids2. Creon will also catalyze the hydrolysis of proteins into peptides and amino acids2. Finally, Creon will take any starches and will do the same thing; catalyze the hydrolysis of the starch into dextrins and other short-chain sugars2. All of the catalyzation of these molecules takes place in the duodenum and proximal small intestine, simulating the digestive enzymes that would be physiologically