The first symptoms of this disease include headaches, vomiting and a fever. Firstly headaches are caused due to pressure on the brain from the swelling of the Menges. Vomiting is the bodies way of trying to wash out and cleanse it from the infection. …show more content…
When inside it can overcome the host defences and adhere to epithelial cells. Transcytosis allows the entry of the bacterial through cells to then allow them to get into the bloodstream. When the bacteria enters the bloodstream it releases toxins into the circulation that then because of a fever. Here the bacteria can cause life-threatening septicemia as they multiply to high density through binary fission. Binary fission is what bacteria's reproduction is called this is the process that carries out cell reproduction and division. This is when the bacteria creates a duplicate of its genetic material then splits into two leaving the same DNA in each bacteria cell. This process then occurs over and over again making numbers start to increase rapidly as it doubles size every time the cells split.you can see the process of this in the photo to the right. The cells will then shed outer membrane in the form of vesicles or blebs. This then causes the host to release inflammatory mediators and cytokines. From the bloodstream, the bacteria can also cross the blood-brain barrier. It will then search to find the meninges surrounding the brain and spinal cord. Here it develops into a large infection. This is done by the bacteria getting into the Menges through the cells and doing similar as to what they did in the bloodstream.