On the other hand, secondary hypertension )which accounts for 5% of the conditions) has a definite cause, …show more content…
The major underlying mechanism for endothelial dysfunction seen in HTN is the decrease in the availability of nitric oxide (NO) which function is vasorelaxation, a consequence of increased oxidative stress in these patients.[1][3][4]
Vasoactive substances:
Endothelin, a potent vasoconstrictor is one of the major substances involved in maintaining vascular tone, it is secreted by endothelial cells and exerts its affects in a paracrine or autocrine manner on vascular smooth muscle cells and counteracts the relaxing activity of