Biochemistry behind the issue - (marked as KU1, KU2, KU3 on …show more content…
Being larger in size than the sodium ion, Tetrodotoxin acts like a plug, preventing the flow of sodium ions until it slowly diffuses off. The sodium channels located on nerve cells are responsible for sensitizing shield. The channels act as gates that regulate the entry of sodium ions across the cell membrane, and is important in the transmission pain intensity signals to the brain. Tetrodotoxin reduces the activity of sense ties nerve cells by selectively reversibly blocking the sodium channels. Although sodium channels are complex structures. Tetrodotoxin selectively binds to the outer for the channel, this block sodium ions from entering the nerve altogether, therefore interrupting or preventing nerve conduction. As a result persistent in chronic pain may be relieved. Without the morphine like side effects associated with existing pain management drugs. (WEX Pharmaceuticals,