The neuron’s anatomy consists of the cell body (also known as the metabolic center of the cell) which contains the nucleus and abundant in nissl substance and neuro-fibrils. There are also the fiber …show more content…
Glioblastoma cells express Ca2+ -permeable AMPA-type glutamate receptors that are involved in the migration response. Their overexpression resulted in migration and proliferation, and their conversion to Ca2+ -impermeable receptors inhibited cell migration and induced apoptosis. So, inhibition of these receptors might prevent glioblastoma invasion (Miller, R., & Perry, A. 2007). Glioblastoma also may arise through 2 distinct pathways of neoplastic progression. Tumors that progress from lower-grade (II or III) astrocytic tumors typically display both well-differentiated and poorly differentiated foci. Secondary GBMs develop in younger patients, with time to progression from lower-grade lesions ranging from months to decades. Primary and secondary GBMs also harbor distinct molecular genetic