There are few reports of Cl- channels in gastrointestinal smooth muscle cells and one report that directly states that Cl- currents could not be detected in smooth muscle cells from mouse small intestine (Tokutomi et al 1995). In the light of an increased understanding of the activities and distribution of Cl- channels and transporters in gastrointestinal smooth muscle, we tested the effects of two anionic substitutes for Cl-, gluconate and isethionate, on the electrical activity of mouse small intestine. These ions are not transported by Cl- ion exchangers (Owen and Prastein 1985, Koncz and Daugirdas 1994) and permeate poorly through Cl- channels (Pezier et al 2010, Reyes 2010, Greenwood and Large 1999). The objective of these studies was to establish the relative contributions of Cl- selective ion channels and transporters in smooth muscle and ICC to the overall electrical activity in circular muscle from mouse small
There are few reports of Cl- channels in gastrointestinal smooth muscle cells and one report that directly states that Cl- currents could not be detected in smooth muscle cells from mouse small intestine (Tokutomi et al 1995). In the light of an increased understanding of the activities and distribution of Cl- channels and transporters in gastrointestinal smooth muscle, we tested the effects of two anionic substitutes for Cl-, gluconate and isethionate, on the electrical activity of mouse small intestine. These ions are not transported by Cl- ion exchangers (Owen and Prastein 1985, Koncz and Daugirdas 1994) and permeate poorly through Cl- channels (Pezier et al 2010, Reyes 2010, Greenwood and Large 1999). The objective of these studies was to establish the relative contributions of Cl- selective ion channels and transporters in smooth muscle and ICC to the overall electrical activity in circular muscle from mouse small