It appears in people who have no other diseases and no family history of bone cancer. Genetic changes: Osteosarcoma is probably caused by a combination of genetic changes. Together, they cause immature bone cells to become tumor cells instead of healthy bone. Osteosarcoma may start because of overactive bone cells. A gene known as RB may be associated with osteosarcoma. This gene is abnormal in many children with a rare type of eye cancer called retinoblastoma. RB is a tumor-suppressor gene that controls cell growth. When it is changed, it no longer controls cell growth. As a result, a tumor can
It appears in people who have no other diseases and no family history of bone cancer. Genetic changes: Osteosarcoma is probably caused by a combination of genetic changes. Together, they cause immature bone cells to become tumor cells instead of healthy bone. Osteosarcoma may start because of overactive bone cells. A gene known as RB may be associated with osteosarcoma. This gene is abnormal in many children with a rare type of eye cancer called retinoblastoma. RB is a tumor-suppressor gene that controls cell growth. When it is changed, it no longer controls cell growth. As a result, a tumor can