There are a range of factors that cause Osteoporosis, these are Estrogen: If the level of estrogen drops then bone loss accelerates and can lead to Osteoporosis. Having both ovaries removed in a process known as bilateral oophorectomy, results in low bone density. In the case of males, testosterone is converted to bone-preserving estrogen, so normal levels of both these hormones are important to prevent osteoporosis.
Hormones: Parathyroid and growth hormones help regulate how well your bones use calcium and when to build or break them