Genome is relatively long and single stranded coding region is bracketed by short palindromic terminal sequences capable of folding into hair pin duplex. The parvovirus replication begins with attachment and genome enters in a host cell, replication occurs in the nucleus. Their DNA must be a replicon. Parvovirus replicate their DNA through a sequence of duplex. For replication 3’ end serves as a primer due to the looping hairpin structure, helicase opens up 5’ end for polymerase activity. Concatermeric genomes are formed by unidirectional, quasi-circular rolling mechanism. VP3 latches on to DNA for encapsidation. Parvoviruses integrate into cellular DNA at high frequency to establish a stable latent state, they will infect cells that replicate quickly. Finally, the assembled capsid promotes the replication shift from synthesizing duplex DNA to single negative sense strand, which will be packed in with virion and will be released upon lysis of
Genome is relatively long and single stranded coding region is bracketed by short palindromic terminal sequences capable of folding into hair pin duplex. The parvovirus replication begins with attachment and genome enters in a host cell, replication occurs in the nucleus. Their DNA must be a replicon. Parvovirus replicate their DNA through a sequence of duplex. For replication 3’ end serves as a primer due to the looping hairpin structure, helicase opens up 5’ end for polymerase activity. Concatermeric genomes are formed by unidirectional, quasi-circular rolling mechanism. VP3 latches on to DNA for encapsidation. Parvoviruses integrate into cellular DNA at high frequency to establish a stable latent state, they will infect cells that replicate quickly. Finally, the assembled capsid promotes the replication shift from synthesizing duplex DNA to single negative sense strand, which will be packed in with virion and will be released upon lysis of