One of these mechanism , oxidative stress, which disturbs the antioxidant defense system and produces reactive oxygen species (ROS), including hydrogen peroxide, superoxide, and hydroxyl radicals (13, 14).Benzene and related hydrocarbons are metabolized through an intermediate epoxide, which is highly reactive and possibly binds to hepatic microsomal proteins and nucleic acids leading to cytotoxic effects (15). An increase in the levels of liver diagnostic parameters in this study might be due to toxic effect on the membrane of liver cell where petroleum hydrocarbons may have been converted into free radicals or activated metabolites during their oxidation (16) .Also, it has been observed that there were degenerative changes in renal and hepatic functions after exposing rats to light and heavy petrol (17) . An increase of serum creatinine in subjects exposed to gasoline vapor indicate renal pathology, and confirm the result of Bartimaeus and Jacobs (18)
One of these mechanism , oxidative stress, which disturbs the antioxidant defense system and produces reactive oxygen species (ROS), including hydrogen peroxide, superoxide, and hydroxyl radicals (13, 14).Benzene and related hydrocarbons are metabolized through an intermediate epoxide, which is highly reactive and possibly binds to hepatic microsomal proteins and nucleic acids leading to cytotoxic effects (15). An increase in the levels of liver diagnostic parameters in this study might be due to toxic effect on the membrane of liver cell where petroleum hydrocarbons may have been converted into free radicals or activated metabolites during their oxidation (16) .Also, it has been observed that there were degenerative changes in renal and hepatic functions after exposing rats to light and heavy petrol (17) . An increase of serum creatinine in subjects exposed to gasoline vapor indicate renal pathology, and confirm the result of Bartimaeus and Jacobs (18)