This shows greater cytotoxic activity and the potency of the analogues was three times greater than the drug. Both correspondents had an acetyl groups attached at the R’ position, and at the R position one (IC50=3.0) had a cyclopropane carboxamide attached, the other (IC50=3.2) had an electron rich heteroaryl amide compound attached6. From this study, it was found that increasing the steric hindrance of the substituents at the C-22 position decreased the cytotoxic activity in the A549 cell line6. Also different aryl/alkyl- substitutions6 at the C-22 position had an influence on its cytotoxic
This shows greater cytotoxic activity and the potency of the analogues was three times greater than the drug. Both correspondents had an acetyl groups attached at the R’ position, and at the R position one (IC50=3.0) had a cyclopropane carboxamide attached, the other (IC50=3.2) had an electron rich heteroaryl amide compound attached6. From this study, it was found that increasing the steric hindrance of the substituents at the C-22 position decreased the cytotoxic activity in the A549 cell line6. Also different aryl/alkyl- substitutions6 at the C-22 position had an influence on its cytotoxic