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People were getting used to Christians and many people already knew about them. By the third century Christian literature has been directed against heresy and paganism, and in favor of Christian thought, which is particularly emphasized by the Christian school of Alexandria and its famous teacher Origen, which connects the lines of early Christian period to the new spirit that is manifested in the Church. Persecutions were run by the emperors Valerian and Aurelian as well, but the greatest persecution of Christianity was experienced during Diocletian and his co-ruler and associates (284-311), particularly Galerius. However, Christianity has spread so much by Diocletian’s time that Christians already existed at his court. Finally, the Emperor Constantine the Great brings freedom to Christianity with the Edict of Milan in 313. He was one of the most important personalities of his time, and undoubtedly in Christianity. He was a Christian, probably Arian. He transferred the center of the Roman Empire from Rome to Constantinople and influenced the development of Christianity in that period.