When there are multiple primary endpoints, it is important to take multiplicity into consideration because disregarding it may give false results. The role of the primary endpoint determines whether or not adjustment for multiplicity is needed. When there is a single primary endpoint with additional endpoints that only support or explore information, adjustment for multiplicity is not necessary. Additionally, adjustments for multiplicity are not needed when co-primary endpoints are used to explore treatment mechanisms, examine secondary hypotheses, or gain information to generate hypotheses for future studies
When there are multiple primary endpoints, it is important to take multiplicity into consideration because disregarding it may give false results. The role of the primary endpoint determines whether or not adjustment for multiplicity is needed. When there is a single primary endpoint with additional endpoints that only support or explore information, adjustment for multiplicity is not necessary. Additionally, adjustments for multiplicity are not needed when co-primary endpoints are used to explore treatment mechanisms, examine secondary hypotheses, or gain information to generate hypotheses for future studies