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what are the 4 stages of bone remodelling
1. Quiescence
2. Resorption
3. Reversal
4.Formation
what processes occur in bone remodelling for quiescence to become resorption
osteoclast:
-recruitment
-differentiation
-activation
what processes occur in bone remodelling for resorption to become reversal
osteoclast
-apoptosis
-removal
in terms of osteoblasts, what happens in the reversal stage of bone remodelling
osteoblast:
what happens for reversal to become formation in bone remodelling
matrix synthesis
what happens for formation to become quiescence
mineralisation
what ligand/receptor do osteoclast progenitor cells have
they have receptor RANK for RANKL ligand on osteoblasts
what ligand/receptor do osteoblast cells have
RANKL ligands which joins with receptors on the osteoclast progenitor cells
what happens when RANK on (osteoclast progenitor cells) and RANKL (on osteoblasts join)
it initiates cell fusion as well as the formation of multi-nucleated osteoclasts.
what are the 2 things which regulate bone remodelling
oestrogen and OPG
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