1. Effects on gastrointestinal function and ulcers:-
Aloe gel is commercially offered for oral consumption and many claims were made for benefits in various internal inflammatory conditions. Trial done on human patient showed a tonic effect on the intestinal tract with a reduced transit time. Also the bacterial flora appears to show benefit, with a reduction in a presence of yeasts and reduction in pH. Bowel putrefaction was decreased and protein digestion/absorption was improved.
An early trial with human patients found oral administration of aloe gel effective in the treatment of peptic ulcers. The anti-ulcer activities of Aloe Vera has been attributed to several possible mechanisms including its healing effects, anti-inflammatory properties, …show more content…
Gastroprotective activity was only observed at the least dose tested. It has been suggested that the Aloe Vera extract have cytoprotective activity at the low concentration, therefore protection against mucosal injury by means of a mechanism different from gastric acid inhibition and neutralisation. Several mechanism have been given for the cytoprotection, namely increased mucosal blood flow, increased mucus synthesis and increased phospholipid content of the mucosal coating. But the exact mechanism is not known.
2. Wound healing effects: It is a respond to injured tissue that results in the restoration of tissue integrity. It was shown that Aloe gel could enhance wound healing after topical and systemic administration in several studies. Several mechanisms has been suggested for the wound healing effects of Aloe gel, which inlude increase epithelial cell migration, keeping the wound moist, more rapid maturation of collagen and reduction in inflammation. The epidermis is repaired in three phases: cell migration, proliferation and maturation, while new connective tissue is found in the …show more content…
It should be noted that macrophages can also secrete substances which can similarly stimulate fibroblast. Whether its effect is direct or indirect, formation of new collagen takes place between the margins of wound when aloe is present. That collagen bond is responsible for increasing the tensile strength. If tensile strength will increase it was assume that collagen production is increased by aloe.
Whenever skin is injured, fibroblast starts migrate into the wound area to proliferate and produce collagen as well as proteoglycans. Proteoglycans helps in formation of ground substances in which collagen fibres are embed. This causes the remodelling of connective tissue. Cells present in the wound area communicate with each other by growth factors. Growth factor in Aloe attract to the wound area and binding takes place with fibroblast IGF receptor for the production of collagen and proteoglycans which causes increase in the tensile
Aloe gel is commercially offered for oral consumption and many claims were made for benefits in various internal inflammatory conditions. Trial done on human patient showed a tonic effect on the intestinal tract with a reduced transit time. Also the bacterial flora appears to show benefit, with a reduction in a presence of yeasts and reduction in pH. Bowel putrefaction was decreased and protein digestion/absorption was improved.
An early trial with human patients found oral administration of aloe gel effective in the treatment of peptic ulcers. The anti-ulcer activities of Aloe Vera has been attributed to several possible mechanisms including its healing effects, anti-inflammatory properties, …show more content…
Gastroprotective activity was only observed at the least dose tested. It has been suggested that the Aloe Vera extract have cytoprotective activity at the low concentration, therefore protection against mucosal injury by means of a mechanism different from gastric acid inhibition and neutralisation. Several mechanism have been given for the cytoprotection, namely increased mucosal blood flow, increased mucus synthesis and increased phospholipid content of the mucosal coating. But the exact mechanism is not known.
2. Wound healing effects: It is a respond to injured tissue that results in the restoration of tissue integrity. It was shown that Aloe gel could enhance wound healing after topical and systemic administration in several studies. Several mechanisms has been suggested for the wound healing effects of Aloe gel, which inlude increase epithelial cell migration, keeping the wound moist, more rapid maturation of collagen and reduction in inflammation. The epidermis is repaired in three phases: cell migration, proliferation and maturation, while new connective tissue is found in the …show more content…
It should be noted that macrophages can also secrete substances which can similarly stimulate fibroblast. Whether its effect is direct or indirect, formation of new collagen takes place between the margins of wound when aloe is present. That collagen bond is responsible for increasing the tensile strength. If tensile strength will increase it was assume that collagen production is increased by aloe.
Whenever skin is injured, fibroblast starts migrate into the wound area to proliferate and produce collagen as well as proteoglycans. Proteoglycans helps in formation of ground substances in which collagen fibres are embed. This causes the remodelling of connective tissue. Cells present in the wound area communicate with each other by growth factors. Growth factor in Aloe attract to the wound area and binding takes place with fibroblast IGF receptor for the production of collagen and proteoglycans which causes increase in the tensile