In fact, if the brain undergoes significant changes in shape, size and structure, as in the case of neonatal brain during early development (17), it has no reliable folding patterns to drive the registration in the case of registration-based parcellation or to rely on in the case of segmentation-based parcellation. Moreover, parcellating it based on a mature brain template introduces a bias since several studies suggested that developing brain analysis needs to be independently performed than mature brain due to significant differences in brain tissue properties, image intensities appearance, and anatomical shapes (23, 127,
In fact, if the brain undergoes significant changes in shape, size and structure, as in the case of neonatal brain during early development (17), it has no reliable folding patterns to drive the registration in the case of registration-based parcellation or to rely on in the case of segmentation-based parcellation. Moreover, parcellating it based on a mature brain template introduces a bias since several studies suggested that developing brain analysis needs to be independently performed than mature brain due to significant differences in brain tissue properties, image intensities appearance, and anatomical shapes (23, 127,