Introduction:
Overall, Fall Semesters Freshman Engineering course, Engineering Graphics and Design 110 deals with the scientific process, which is a highly concentrated methodology focusing on the five-step Engineering Design Process. The five-step Engineering Design Process has been constructed to provide a rigorous, repeatable, formal scientific methodology to engineering problems. These steps are as follows: Define the Problem, Gather Information, Generate Multiple Solutions, Analyze and Select a Solution, and Test and Implement the Solution.
This design process is a basic, structured formula, so to speak, that provides a building-block, additive procedure for projects from ideas to real-life structures and solutions. When designing and …show more content…
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Engineering Design Process in Context:
“Ligaments play an important role in stabilizing and balancing knee joint movement. Anterior cruciate ligament (ACL) injuries remain a challenge in clinical and experimental settings due to the poor healing potential of ACL injuries.” This introductory sentence, found in the Abstract, sums up the first step of the design process: Defining the Problem. This defines the need for a quicker, more reliable solution to fixing damaged ACLs, instead of the high failure rate commonly seen.
“Recent studies have reported that growth factors can improve patient outcomes after the surgical repair of ACL injuries. Growth factors have been tested for orthopedic treatments such as fracture management, spinal fusion and tendon and ligament healing. Growth factors, such as transforming growth factor-beta (TGF-β) [10], platelet derived growth factor (PDGF) [11] and vascular endothelial growth factor (VEGF) [12], show the most promising results for healing ACL injuries [13]. Biochemical factors that can be added to tissue-secreted proteins may offer opportunities to improve ACL injury repair and to promote regeneration in clinical …show more content…
MGF-C24E is formed when total IGF-1 mRNA contains 6 exons and can be translated into a precursor that cleaves to form the N-terminal peptide named mature IGF-1, and a C-terminal fragment named E-peptide. IGF-1 splice variants of exon 4 spliced to exon 5 or exon 6 are named MGF or IGF-IEc in humans and IGF-IEb in rodents [15], [16] and [17].” This section, located towards the end of the Introduction, represents a section of other studies that have the same objectives as the Mechano Growth Factor has. This shows that there have been Multiple Solutions Generated to fix the healing process of the ACL
Overall, Fall Semesters Freshman Engineering course, Engineering Graphics and Design 110 deals with the scientific process, which is a highly concentrated methodology focusing on the five-step Engineering Design Process. The five-step Engineering Design Process has been constructed to provide a rigorous, repeatable, formal scientific methodology to engineering problems. These steps are as follows: Define the Problem, Gather Information, Generate Multiple Solutions, Analyze and Select a Solution, and Test and Implement the Solution.
This design process is a basic, structured formula, so to speak, that provides a building-block, additive procedure for projects from ideas to real-life structures and solutions. When designing and …show more content…
249-261
Engineering Design Process in Context:
“Ligaments play an important role in stabilizing and balancing knee joint movement. Anterior cruciate ligament (ACL) injuries remain a challenge in clinical and experimental settings due to the poor healing potential of ACL injuries.” This introductory sentence, found in the Abstract, sums up the first step of the design process: Defining the Problem. This defines the need for a quicker, more reliable solution to fixing damaged ACLs, instead of the high failure rate commonly seen.
“Recent studies have reported that growth factors can improve patient outcomes after the surgical repair of ACL injuries. Growth factors have been tested for orthopedic treatments such as fracture management, spinal fusion and tendon and ligament healing. Growth factors, such as transforming growth factor-beta (TGF-β) [10], platelet derived growth factor (PDGF) [11] and vascular endothelial growth factor (VEGF) [12], show the most promising results for healing ACL injuries [13]. Biochemical factors that can be added to tissue-secreted proteins may offer opportunities to improve ACL injury repair and to promote regeneration in clinical …show more content…
MGF-C24E is formed when total IGF-1 mRNA contains 6 exons and can be translated into a precursor that cleaves to form the N-terminal peptide named mature IGF-1, and a C-terminal fragment named E-peptide. IGF-1 splice variants of exon 4 spliced to exon 5 or exon 6 are named MGF or IGF-IEc in humans and IGF-IEb in rodents [15], [16] and [17].” This section, located towards the end of the Introduction, represents a section of other studies that have the same objectives as the Mechano Growth Factor has. This shows that there have been Multiple Solutions Generated to fix the healing process of the ACL