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in muscles what is the "unit" of contraction
the SARCOMERE
in terms of filaments in muscle, what are the central filaments which stay stationary and what are the filaments which protrude in from Z lines on either side called?
stationary + central filaments = myosin
sliding filaments which portrude from Z lines on either side = actin
active shortening against load requires the presence of what
cross-bridges (XBs)
how does the cross bridge interact between myosin and actin monomers
cross bridges (XBs) reach out from MYOSIN filament to interact with ACTIN “monomers” (individual molecules) in thin filament
the cross bridge interaction is only possible after what event has taken place?
Ca2+ binds to troponin--> moving tropomyosin
describe the the working stroke is in terms of cross bridges
the myosin head pivots and bends as it pulls on the actin filament- thus sliding it towards the M line (M line is centre remember)
when does the cross bridge detach from the actin monomer
when the ATP attaches
when ATP in the myosin head is hydrolysed and split into ADP and Pi, what characteristic movement of the myosin head occurs
cocking of the myosin head occurs
from where does the force for the "bend" in the myosin head occur
within the XBs
with the force generated at ATPase site
what are the names given to the XB and the link subsequently
XB --> S1 subunit
link-->S2
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