In David Cyranoski’s article from 29th September, 2015 on Nature.com website , he mentioned that a famous genomics institute in Shenzhen is going to sell gene-edited miropigs as pets, and each costs $10,000 yuan (US$1,600). The customers can choose unequal coat colours and patterns of pigs through their gene arrangement subsequently. Those pigs not only can be our pets, but also were fabricated as models for human disease by using a gene-editing tool --- TALENs. Geneticists make use of TALENs to…
this disease, let us look at the history of sickle cell disease. One type of sickle cell disease is sickle cell anemia. Anemia means a few abnormal amounts of red blood cells. The name sickle cell anemia is first coined in 1910 by U.S. physician James Bryan Herrick. In one of his severe anemia cases, he found abnormal shaped red blood cells. He described them as sickle-shaped cells. By 1949, U.S. physical chemist Linus Pauling displayed that hemoglobin in people with sickle-cell disease differed…
those 300 million individuals, 100,000 Americans are affected by sickle cell disease, making it the most common inherited blood disorder. Every single cell in our body needs oxygen to function efficiently, and the role of hemoglobin in red blood cells is to transport oxygen from the lungs to the rest of the body (“Sickle Cell Disease”, 2016). In a normal individual, the red blood cells have a disc-like shape that grant it flexibility and allow it to move through the smallest of vessels. However,…
The Crescent Moon Disease: Sickle Cell Sickle cell anemia is a disease that is passed throughout families. Sickle cell affects the red blood cells, which cause the blood cells to look like a crescent moon instead of looking like a disc, like the photo included above. There are two types of Sickle cell: Sickle Cell Anemia and Sickle Cell- Hemoglobin C. Sickle Cell Anemia is the less severe one out of the two. Sickle Cell Anemia affects many racial and ethnic groups. One in four hundred…
researching medicine even at a young age. He graduated the University of Vienna in 1891, at the age of 23. He studied medicine and while at the university he started his findings on biochemical. He also published a paper on the diet on the composition of blood ash that same year. He wanted to learn more on chemistry so over the next five years he studied with other brilliant chemist like Arthur Rudolf Hantzsch at Zurich, Hermann Emil Fischer at Wurzburg, and Eugen Bamberger at Munich. By the…
infects red blood cells. This disease is inherited disease in which the body is unable to produce normal hemoglobin (1).There are several names for this disease such as sickle cell anemia. This disease spreads in inbreeding because it is a genetic disease. This disease is called sickle cell because the red blood cells under a microscope take a curved or crescent shape like a sickle (tool for harvesting forage).The cells are stiff and sticky and often clogs the blood flowing in the blood vessels…
started in 1910.When a patient from the West Indies had anemia characterized by oddly shaped red blood cells. A Chicago physician, James B. Herrick identified the red blood cells as sickled shaped. It was discovered that the sickling of the cells was associated with the low oxygen in 1927 by Hahn and Gillespie. A medical student at John Hopkins, Sherman, noticed the birefringence of deoxygenated red blood cells, recommended that low oxygen adjusted the hemoglobin structure in the molecule. In…
hereditary disease is sickle cell disease. Sickle Cell Disease is the most prominent hereditary blood disorder in the world. Sickle cell disease is a group of differently combined disorders that affect the hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape ( U.S. National Library of Medicine)…
Sickle Cell Disease (SCD) is an inherited blood disorder, in which people have abnormal hemoglobin. This causes a variety of problems for the person throughout their entire life, but severity of the disease varies. Sickle Cell Disease is not necessarily deadly, but it decreases the average life expectancy of a persson. In countries like the United states, a person with Sickle Cell Disease has a life expectancy of about forty to sixty years. Other than stem cell transplants there is no cure…
immigration. This disease is most common in men. The condition of SCD makes the abnormal red blood cells not function properly. The life span of a person with SCD is shortened. This disease is a global health problem.There was a non - funded neonatal screening program for all the children identified SCD in Republic of Ireland born after 2005. The screening helped to compare and review all the kids with this blood disorder from 2009 to 2012. There were a lot of statistics in the article,…