In 1981 term 'filaggrin' was used to describe the whole class of proteins that had been found in a stratum corneum. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721001/) Filaggrin tends to associate with keratins, which take part in a formation of a scaffold. However, actin filaments or microtubules are not associated to filaggrin molecules. The synthesis of filaggrin begins with a large, insoluble precursor molecule, called profilaggrin, which can be found in stratum granulosum. During the cell maturation, profilaggrin is proteolysed into filaggrin as well as dephosphorylated. Now the filaggrin molecule become active and associates to keratin filaments. Such association causes the formation of highly insoluble keratin matrix and tight association between the
In 1981 term 'filaggrin' was used to describe the whole class of proteins that had been found in a stratum corneum. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721001/) Filaggrin tends to associate with keratins, which take part in a formation of a scaffold. However, actin filaments or microtubules are not associated to filaggrin molecules. The synthesis of filaggrin begins with a large, insoluble precursor molecule, called profilaggrin, which can be found in stratum granulosum. During the cell maturation, profilaggrin is proteolysed into filaggrin as well as dephosphorylated. Now the filaggrin molecule become active and associates to keratin filaments. Such association causes the formation of highly insoluble keratin matrix and tight association between the