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42 Cards in this Set
- Front
- Back
Immunity |
The ability to resist infection and diseases. |
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Immediate hypersensitivity (type 1) Antibody mediated hypersensitivity (type 2) Immune complex-mediated hypersensitivity (type 3) T cell mediated hypersensitivity (type 4) |
What are the 4 types of hypersensitivity |
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Degranulation |
It results in histamine release, which increases vascular permeability. |
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Hypersensitivity reactions |
Adverse reactions caused by immune mechanisms are termed? |
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Platelet aggregation |
It causes microthrombus formation and leads to the release of vasoactive amines from platelet-dense granules. |
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Complement-fixing antibodies |
It react directly with antigens that are integral components of the target cell. |
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Angiodema |
It is the acute edema of cutaneous or mucosal structures, most commonly involving the lips and eyelids. |
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Anaphylactic shock |
Systemic anaphylaxis also known as? |
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Serum sickness |
It is a systemic deposition of antigen-antibody complexes in multiple sites, especially the heart, joints, and kidneys. |
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Distinguish self from non-self Discriminate among potential invaders Generate immune memory and amplification responses |
Immune responses are characterized by their capacity to: |
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Immunodeficiency |
Term used to decribe if the immune system is deficient. |
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Innate immunity Adaptive immunity |
2 types of reactions of defense against microbes. |
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Skin prick allergen testing |
It is a test used to know allergies |
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Hypersensitivity diseases |
Immune responses that are capable of causing tissue injury and diseases are called? |
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Epithelial barriers Phagocytic leukocytes Natural killer cell Complement system |
The 4 major components or the innate immunity are: |
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IgA |
What immunoglobulin is the major isotype in mucosal secretions? |
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Dendritic cells |
Are major cells for displaying protein antigens to naive T cells to initiate immune response? |
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Generative or primary organs Peripheral or secondary organs |
The lymphoid tissue is divided into two organs namely: |
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Immediate response phase |
This phase is characterized by vasodilation, vascular leakage and smooth muscle spasm, evident within 5-30mins after exposure to an antigen. |
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Autoimmunity |
It is an immune reaction to self antigens |
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Central tolerance |
This refers to the deletion of self-reactive T and B lymphocytes during their maturation in central lymphoid organs. |
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Type Diabetes Mellitus |
It is strongly associated with HLA-DR3 or HLA-DR4 |
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Molecular mimicry |
What phenomenon shares a cross-reacting epitopes with self-antigens? |
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Systemic Lupus Erythematosus |
It is a multisystem autoimmune disease of variable behavior. It affects the skin, kidneys, serosal membranes, joints, and heart. |
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DNA Histones Nonhistone proteins bound to RNA Antibodies to nuclear antigens |
What are the 4 categories that ANAs are grouped into? |
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Indirect immunofluorescence |
What is the most common method to detect antinuclear antibodies? |
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Monogeneous or diffuse |
_____ staining usually reflacts antibodies to chromatin, histones, and dsDNA |
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True |
Kidney involvement is one of the most important clinical features of SLE with renal failure being the most common cause of death. (True or False) |
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Class IV |
Diffuse proliferative glomerulonephritis (35% to 60%); most serious form belongs to what class? |
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CNS disease |
It is often ascribed to vascular lesions causing ischemia or multifocal cerebral microinfarcts. |
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Libman-Sacks endocarditis |
Myocarditis, in the form of a non specific mononuclear cell infiltrate, and valvular lesions, is called? |
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Rhuematoid Arthritis |
It is a systemic, chronic inflammatory disease affecting many tissues but principally attacking the joints to produce a nonsuppurative proliferation synovitis that frequently progresses to destroy articular cartilage and underlying bone with resulting disabling arthritis. |
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Serositis, Oral ulcers, Arthritis, and Photosensitivity |
In the criteria for SLE, we use SOAP-BRAIN-MD. What does SOAP stands for? |
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Hemophilia |
In the criteria for SLE, which blood abnormality does not belong in the group? |
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Systemic Lupus Erythematosus |
It is a fairly common disease. Like many autoimmune diseases, there is a strong (approximately 9:1) female preponderance. |
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True |
The joint inflammation in RA is immunologically mediated.(true or false) |
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Cardiogenic Hypovolemic Septic |
What are the general categories of shock? |
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Nonprogressive stage Progressive stage Irreversible stage |
What are the stages of shock? |
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Albumin |
What serum protein is most responsible for maintaining intravascular colloid osmotic pressure? |
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GP IIb/IIIa |
A defect in what glycoprotein platelet membrane receptor causes Glanzmann thrombasthenia? |
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Collage Exposure |
This activates the platelets and initiates the contact phase of coagulation. |
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Vegetation |
Thrombi heart valves are called. |