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26 Cards in this Set
- Front
- Back
Abeta fiber
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mechanoreceps
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Adelta
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fast mechano and noci
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C fibers
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nociceptors, thermoceptors, mechanoceptors
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Mechanoceptors
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turn on interneuron
slow down pain transmission |
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LC
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locus ceruleus
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NRPG
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nucleus reticularis paragigantocellularis
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PAG
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periaquaductal grey cortex
controls ones affective response can enhance pain response can attenuate pain Electrical stimulation cause analgesia |
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Enkephlin
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Put electrodes in PAG with it
cause analgesia natural body opioid |
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Naloxone
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Opioid recep antagonist
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CGRP
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Calcitonin gene related peptide
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Substance P
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most popular pain transmitter
NK1 its release activated Ca2+ inside neuron --> activates number of pathways NO synthase increased by Ca2+: magnifies stimulus |
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Norepinephrine
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alpha recep located presynap to dec release of pain
located post synap to dec firing rate |
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Glutamate
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PAIN
NMDA and AMDA |
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Ketamine
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blocks NMDA ion channel
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NSAID
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blocks COX2
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Opioids
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act on nu, kappa, delta receps
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Capsaicin
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analgesic yet a pain inducer
depletes substance p! similar to vanillin vanilloin receptor |
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bradykinin
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peptide
pain transmitter injected locally or systemically to induce pain |
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Seratonin
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Seratonin 3 recep
only ION recep |
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ATP
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purinergic recep
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H+ ion recept
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changes pH
Acid sensing ion channel |
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Heat
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vanilloid recep heat sensing
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pressure
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epithelium sodium channel recep
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substance p
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degranulates histamine containing mast cells
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Pain receptors are...
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in the periphery
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CGRP and Serotonin
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released locally before signal gets to spinal cord
Pain: reaches spinal cord, antidromic transmission |