Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
32 Cards in this Set
- Front
- Back
What is pharmacoDYNAMICS?
|
What the chemical does to the body, mechanism of action
|
|
What is pharmacoKINETICS?
|
What the body does to the chemical, time course and dynamics of the drug, absorption, distribution
|
|
Cimetidine causes
|
Reduced gastric secretion
|
|
What does aspirin do?
|
Covalently alkylates cyclooxygenase
|
|
Weak binders are usually more selective
|
NOTES
|
|
What does DAG (diacylglycerol) do?
|
Activates Protein Kinase C (PKC)
|
|
Nicotinic aceylcholine receptor is what type of channel?
|
Na+ channel
|
|
GABA receptor is what type of channel?
|
Cl- channel
|
|
cAMP is a 2nd messenger that activates
|
PKA and ion channel
|
|
cGMP activates
|
protein kinase G (PKG)
|
|
Guanylyl cyclase is acivated by
|
NO
|
|
Equation for Vd
|
Amount of drug in body/Plasma drug concentration
|
|
Equation for Clearance
|
Rate of elimination/plasma drug concentration
|
|
Half life equation
|
(0.693 x Vd)/CL
|
|
Maintenance Dosage Equation
|
Dosing Rate = (CL x Desired plasma concentration)/ Bioavailability
|
|
Loading Dose equation
|
Loading dose = (Vd x desired plasma concentration) / Bioavailability
|
|
Examples of receptors that are protein kinases
|
EGF (epidermal growth factor) receptor
Cytokine receptor |
|
Examples of ion channel receptors
|
1) Nicotinic receptor
2) GABA 3) Glu 4) Asp 5) Gly |
|
What does phosphodiesterase do?
|
Cleaves cAMP
|
|
cAMP activates
|
Protein kinase A and ion channels
|
|
cGMP activates
|
Protein Kinase G
|
|
Chronic application of agonists on receptors causes
|
Desensitization and tachyphylaxis
|
|
Chronic application of antagonists on receptors causes
|
Supersensitivity and rebound effect
|
|
Lower ED50 means
|
Higher POTENCY
|
|
Remember ED50 means apparent AFFINITY of drug to receptor
|
Notes
|
|
Potency means
|
How much of the drug you need to occupy half of the receptors
|
|
Partial agonists compete with full agonists
|
Notes
|
|
Same slopes indicates same mechanisms
|
Notes
|
|
half life equation 2
|
.693/rate of elimination (slope) on a log scale
|
|
Albumin is the major binding protein for acidic, basic, or neutral drugs?
|
Neutral AND acidic drugs
|
|
Basic drugs bind what in plasma
|
alpha-1-acid glycoprotein
|
|
Ke =
|
CL/Vd
|