Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
107 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
etomidate |
|
|
|
|
□ ketamine |
|
|
|
|
□ phenobarbital |
|
• 5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
• 5,5-, 1,5,5- 치환만 수면·항불안·마취 효능 • 5-, 1,3-, 1,3,5,5- 는 불활성 또는 경련유발 • pH 에 따라 3개의 lactam group이 lactim으로 변화 • 5번 탄소 치환기의 탄소수↑, 질소 치환기의 탄소수↑ : 지용성↑ • N에 큰 알킬기는 경련유발, N1, N3모두 치환시 불활성
• 2-phenybutyronitrile 원료 • benzyl cyanide(phenylacetonitrile) 원료 • urea(thiopental 제외, barbiturate, trimethadione) 원료 • diethylmalonate 아님! |
|
|
□ zolpidem |
|
• N,N-dimethyl-2-(6-methyl-2-p-tolylimidazopyridin-3-yl)acetamide
• Mannich reaction • 4-Methylphenacetyl bromide 원료 • 2-amino-5-methylpyridine 원료 |
|
|
□ diazepam |
|
• 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
• 링A - 방향성고리 필요. 7번에 EWG 도입시 활성유지. 6,8,9번에 EWG 도입시 활성상실. • 링B - 1번 치환기는 활성과 무관하지만 bulky하면 친화력↓. 2번에 proton acceptor(carbonyl,sulfinyl)필요. 3번에 hydroxyl 도입시 대사 빠르고 ester화 가능. 4,5번 이중결합 포화시 친화력↓ • 링C - 수용체 결합에 필요한 구조는 아님. 입체적으로 도움. 2’에 EWG 도입시 활성유지. 4’에 EWG 도입시 활성감소. 링C는 heteroaromatic, cycloalkenyl 가능.
• Friedel-Crafts acylation • 2-amino-5-chloro-benzophenone 원료 • glycine ethyl ester 원료 • 2-Amino-5-chlorobenzoic acid 원료 • benzoyl chloride 원료 |
|
|
□ lorazepam |
|
• (RS)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 링A - 방향성고리 필요. 7번에 EWG 도입시 활성유지. 6,8,9번에 EWG 도입시 활성상실. • 링B - 1번 치환기는 활성과 무관하지만 bulky하면 친화력↓. 2번에 proton acceptor(carbonyl,sulfinyl)필요. 3번에 hydroxyl 도입시 대사 빠르고 ester화 가능. 4,5번 이중결합 포화시 친화력↓ • 링C - 수용체 결합에 필요한 구조는 아님. 입체적으로 도움. 2’에 EWG 도입시 활성유지. 4’에 EWG 도입시 활성감소. 링C는 heteroaromatic, cycloalkenyl 가능.
• 2-(2-chlorobenzoyl)-4-chloroaniline 원료 • diethyl-2-aminomalonate 원료 |
|
|
□ alprazolam |
|
• 8-chloro-1-methyl-6-phenyl-4H-triazolobenzodiazepine
• 2-amino-5-chloro-benzophenone 원료 • glycine ethyl ester 원료 • acetylhydrazine 원료 |
|
|
baclofen |
|
|
|
|
eperisone |
|
|
|
|
sulpiride |
|
|
|
|
chlorpromazine |
|
|
|
|
□ olanzapine |
|
• 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thienobenzodiazepine
• dibenzodiazepine
• N-arylation • dehydration • propionaldehyde 원료 • malonitrile 원료 |
|
|
quetiapine |
|
|
|
|
□ risperidone |
|
• 4-[2-[4-(6-fluorobenzoisoxazol-3-yl)-1-piperidyl]ethyl]-3-methyl-2,6-diazabicyclodeca-1,3-dien-5-one
• fluorobutyrophenone • 4번 탄소에 3급 아민기 치환 필수 • propyl 사슬 변화시 활성 감소 • carbonyl기 최적
• Friedel-Crafts acylation • N-acylation • Oxime formation • O-arylation • 1,3-Difluorobenzene 원료 • 1-Acetylpiperidine-4-carbonyl chloride 원료 • 2-Aminopyridine 원료 • 3-Acetylbutyrolactone 원료 |
|
|
domperidone |
|
|
|
|
□ carbamazepine |
|
• 5H-dibenzoazepine-5-carboxamide
• Wohl Ziegler reaction (radical reaction) • 2-nitrotoluene 원료 • phosgen 원료 |
|
|
□ valproic acid |
|
• 2-propylpentanoic acid
• Retro-Claisen reaction • diethyl malonate 원료 • n-propyl bromide 원료 • ethyl acetoacetate 원료 |
|
|
□ lamotrigine |
|
• 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
• Grignard reaction • 2,3-dicholoro-1-iodobenzene 원료 • 2,3-dichlorobenzoic acid 원료 • dichlorosulfoxide 원료 • Cuprous cyanide 원료 • 2,3-dichlorobenzyl cyanide 원료 • aminoguanidine 원료 |
|
|
naloxone |
|
|
|
|
pentazocine |
|
|
|
|
fentanyl |
|
|
|
|
loperamide |
|
|
|
|
levodopa |
|
|
|
|
carbidopa |
|
|
|
|
biperiden |
|
|
|
|
atropine |
|
|
|
|
ipratropium |
|
|
|
|
oxybutynin |
|
|
|
|
donepezil |
|
|
|
|
epinephrine |
|
|
|
|
phenylephrine |
|
|
|
|
salbutamol |
|
|
|
|
formoterol |
|
|
|
|
fenoterol |
|
|
|
|
alfuzosin |
|
|
|
|
propranolol |
|
|
|
|
atenolol |
|
|
|
|
carvedilol |
|
|
|
|
amitriptyline |
|
|
|
|
fluoxetine |
|
|
|
|
paroxetine |
|
|
|
|
ondansetron |
|
|
|
|
sumatriptan |
|
|
|
|
lidocaine |
|
|
|
|
dibucaine |
|
|
|
|
sildenafil |
|
|
|
|
vardenafil |
|
|
|
|
theophylline |
|
|
|
|
ambroxol |
|
|
|
|
montelukast |
|
|
|
|
pranlukast |
|
|
|
|
amiodarone |
|
|
|
|
doxapram |
|
|
|
|
verapamil |
|
|
|
|
diltiazem |
|
|
|
|
nifedipine |
|
|
|
|
amlodipine |
|
|
|
|
enalapril |
|
|
|
|
ramipril |
|
|
|
|
benazepril |
|
|
|
|
valsartan |
|
|
|
|
hydrochlorothiazide |
|
|
|
|
furosemide |
|
|
|
|
simvastatin |
|
|
|
|
atorvastatin |
|
|
|
|
clopidogrel |
|
|
|
|
cilostazol |
|
|
|
|
glimepiride |
|
|
|
|
acetaminophen |
|
|
|
|
aspirin |
|
|
|
|
dexibuprofen |
|
|
|
|
diclofenac |
|
|
|
|
piroxicam |
|
|
|
|
bendazac |
|
|
|
|
sulindac |
|
|
|
|
indomethacin |
|
|
|
|
hydroxyzine |
|
|
|
|
cetirizine |
|
|
|
|
fexofenadine |
|
|
|
|
loratadine |
|
|
|
|
methylphenidate |
|
|
|
|
acyclovir |
|
|
|
|
modafinil |
|
|
|
|
esomeprazole |
|
|
|
|
pyrazinamide |
|
|
|
|
chloramphenicol |
|
|
|
|
orlistat |
|
|
|
|
levofloxacin |
|
|
|
|
methotrexate |
|
|
|
|
ketoconazole |
|
|
|
|
ciprofloxacin |
|
|
|
|
propylthiouracil |
|
|
|
|
fluconazole |
|
|
|
|
imatinib |
|
|
|
|
cyclophosphamide |
|
|
|
|
amoxicillin |
|
|
|
|
levothyroxine |
|
|
|
|
mefloquine |
|
|
|
|
cimetidine |
|
|
|
|
isoniazid |
|
|
|
|
cefaclor |
|
|
|
|
ranitidine |
|
|
|
|
tamoxifen |
|
|
|
|
oseltamivir |
|
|
|
|
5-fluorouracil |
|
|
|
|
doxorubicin |
|
|
|
|
metronidazole |
|
|
