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11 Cards in this Set
- Front
- Back
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What is the Barker hypothesis?
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Babies that are too small are predisposed to adult diseases
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What can placental insufficency lead to...?
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Vascular problems, malnutrition, Inc incidence of CVD in later life
Pre-eclampsia and IUGR |
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Pre-eclampsia
Nutshell? |
Disorder or late pregnancy.
Left untreated may progress to eclampsia, life threatening condition characterised by convulsions 5-10% pregnancies |
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Diagnosis of Pre-eclampsia
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Diagnosed by high BP (>140/90 mmHg) and proteinuria (>300mg/24h)
20 weeks and after in normotensive patients |
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What causes this disease then?
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Abnormal trophoblast invasion in to the maternal tissue
As a result...spiral arteries do not undergo full physiological change and hence blood flow to placenta is reduced |
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Diagram outlining barker hypothesis
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What are the consequences to a baby malnourished in the first trimester?
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Down regulation of growth
Reduced birth weight Small body Raised Blood pressure Die by Haemorrhagic stroke |
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What are the consequences to a baby malnourished in the second trimester?
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Insulin resistance or deficiency
Reduced birth weight Thin body Hypertension, NIDDM Death by CHD |
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What are the consequences to a baby malnourished in the third trimester?
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Brain growth good, trunk no
GH resistance or deficiency Normal birth weight Short body Hypertension, NIDDM, Raised fibronogen etc Death by thrombotic stroke, CHD |
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Three methods to explain poor lung function in adult life
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Dec in utero growth=Dec ling growth= Inc Resp infections = Dec child lung function = Inc decline in Adult lung function
-------------- Poor childhood SES = Poor education = Poor adult SES = Air pollution, poor diet, smoking etc = Inc decline in Adult lung function -------------- Childhood chest illness = Poor education = low SES = as above |
