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16 Cards in this Set
- Front
- Back
4 totally awesome things you need NADPH for
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synthesis of steroid hormones
fatty acid synthesis reduction of glutathione PHAGOCYTOSIS |
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rock star enzymes of the PPP
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transaldolase
transketolase |
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what is that coenzyme that is necessary for the PPP
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TPP
thiamine pyrophosphate (vit B1) needed by transketolase |
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in the PPP, pentose sugars and NADPH are formed in the ____________ stage
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oxidative
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the first enzyme of the PPP
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Glucose 6-phosphate dehydrogenase
G6PD makes one NADPH |
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the 2 glycolytic intermediates produced by the non-oxidative part of the PPP
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Glyceraldehyde 3-phosphate
Fructose 6-P |
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Transketolase
5 + 5 gives you |
3 + 7
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Transaldolase
3 + 7 gives you |
6 + 4
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Transketolase the second time
4 + 5 gives you |
6 + 3
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test for nutritional thymine status
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Transketolase in RBCs
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whats the sugar that's needed for nucleotide synthesis
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ribose 5-phosphate
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do RBCs make use of the nonoxidative phase of the PPP
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yeah, they don't need the ribose 5-phosphates
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2 more things NADPH is good for
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the cytochrome 450 system
synthesis of NO |
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what do WBCs use NADPH for
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making those wicked lytic superoxidases
NADPH oxidase, there deficiency causes chronic granulomatous disease, characterized by chronic infections |
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somebody eats fava beans
or takes oxidant drugs like Sulfa drugs or just gets an infection and their eyes turn yellow. |
oxidative stresses
G6PD deficiency Low NADPH to counter it |
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G6PD A-
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a less severe mutation of the enzyme, compared to the mediterranean type
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