Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
Mechanism to recycle from NADH to NAD+
|
this cna be done in fermentation
|
|
Site of glycolysis
|
cytosol
|
|
Catabolism of pyruvate.
|
in the mitochondria ( carboxylic acids)
|
|
Regulation of glycolysis
Gluconeogenesis Reciprocal regulation of glycolysis and gluconeogenesis. |
the three irreversisbke steps
|
|
Each of irreversible step is regulated
|
so that we don't go break down stuff
|
|
The first step of glycolysis is regulated by AMP and ATP
|
High concentration of ATP inhibit the this
|
|
PFK (phosphofructokinase) has 2 site, catalytic and activate
|
an allo steric enzyme
F-6P + ATP -> F-1,6-BP +ADP |
|
2 ATP bindin sites: 1 catalytic and 1 regulatory
|
ATP bound at regulatory sitelowers affinity for F-6P. AMP reverses inhibition by ATP
|
|
Adenylate kinase
|
ADP + ADP -> ATP + AMP
|
|
Citrate (TCA cycle)
|
enhaces ATP inhibition
|
|
ATP decreases as you excercise
|
Well, so AMP goes up as ADP got converted back
Concentration of lactase increase as well |
|
F1,6BP would increase first and then decrease
|
yup, it's tru
|
|
Gluconeogenesis
|
how non-carbonhydrate precursors ( lactate, etc)
are convereted into glucose Pyruvate -> Glucose Precursors converted to pyruvate or intermediate in pathway to glucose Takes place primarily in Liver ( and to lesser extant the kidney) Important during extended exercise, fasting and starvation. |
|
How do we get around 3 irreversible steps ?
|
Well, 4 additional reaction replaces the 3 irreversible
1. Pyruvate -> Oxaloacetate (OAA) 2, OAA -> PEP (phospho 3. F-1,6-BP -> F-6P 4. G-6P-> Glucose Some aa's, lactate -> pyruvate. Some aa's -> OAA Glycerol form lipids DHAP |
|
Pyruvate ->PEP
1. Pyruvate carboxylase Pyruvate +ATP + CO2 -> OAA + ADP + P1 |
mitochondrial contains biotin, require acetyl CoA
|
|
PEP carbonxykinase OAA + GTP -> PEP + GDP + CO
|
blah blah blah
|