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12 Cards in this Set
- Front
- Back
True or false Cis-acting DNA Sequence Elements regulate the expression of eukaryotic genes. |
True, Reference slide 15/73, they are further divided into promoter and enchancer elements |
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Explain how proteins are like "dimmer switches" |
-combination of transcription factors interacting at a specific gene’s promoter/enhancer sequences
- combination specifies the amount of transcriptional initiation by RNA pol II at that gene in a particular cell type. (when, where, how much)
- very fine function because of these combinations. |
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What is the difference between gene-specific and general transcription factors? |
General: involved in transcription from all polymerase II promoters. They have part of the basic (or general) transcription machinery-involved in formation of the transcription initiation complex (also known as preinitiation complex).
Gene-specific: Not part of the general machinery. - bind to promoter and enhancer elements of one or a small number of different genes, and direct activity of the general transcription factors |
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Which of these components is NOT part of the preinitiation complex?
TAF,TBP, TFIIB, TIIF, TFIIH, H1 |
H1 is part of the Chromatosome |
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True or false, the transcription initiation complex is responsible for the initiation and the rate of General transcription. |
False- the transcription initiation complex is NOT responsible for the rate |
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True or false, Steroid Hormone proteins (contain a helix-turn-helix DNA binding domain) play critical roles in the regulation of gene expression during embryonic development. |
False, this is the definition for Homeodomain proteins,
Steroid Hormone Receptors: contain a zinc finger domain) are transcription factors that regulate gene transcription in response to hormones such as estrogen and testosterone.
- therefore they are not present in embryonic development |
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Transcription factors contain separate DNA-binding and activation/repression domains.
What are 2 general mechanisms of action for Transcription Factors. |
2 general mechanisms of action
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Gene expression in eukaryotic cells is regulated by repressors as well as by transcriptional activators.
True or False, with other transcription molecules |
False, they also function by
Full function below: |
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__________________________is the modification of histones by the addition of acetyl groups to specific lysine residues in histone tails. |
Histone acetylation |
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True or False:A 7-methylguanosine cap is added last during the modification of the 3' end of a transcript, often after transcription has ceased. |
False:A 7-methylguanosine cap is first added during the modification of the 5'end of a transcript, often before transcription has ceased. |
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Find the error in the message: One snRNA complex forms the splicesome, and carry out the splicing reactions |
Multiple snRNP complex forms the splicesome, and carry out the splicing reactions, and what a snRNP is |
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5.8S, 18S, and 28S rRNA
True or False - these ribosomes are spliced in the cell |
False, they are not |