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35 Cards in this Set
- Front
- Back
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Paget disease of nipple |
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Paget disease of nipple (malignant cells circled) |
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Invasive ductal carcinoma (DS = desmoplastic stroma); tubular carcinoma |
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Invasive ductal carcinoma; Mucinous carcinoma |
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Invasive ductal carcinoma; inflammatory carcinoma |
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Invasive ductal carcinoma; inflammatory carcinoma; cancer (circled) within dermal lymphatics |
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Invasive lobular carcinoma (note single file structure) |
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What is the functional unit of the breast? |
The terminal duct lobular unit |
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Acute mastitis |
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Periductal mastitis |
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Mammary duct ectasia |
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How does fat necrosis of breast present? |
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Fibrocystic change |
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Fibrocystic changes associated with increased risk for invasive carcinoma |
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Intraductal papilloma |
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How is intraductal papilloma distinguished from papillary carcinoma? |
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Fibroadenoma |
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Phyllodes tumor |
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Ductal carcinoma in situ (DCIS) |
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Histological appearance of Comedo type DCIS |
comedo type is characterized by high-grade cells with necrosis and dystrophic calcification in the center of ducts |
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Paget disease of breast |
DCIS that extends up the ducts to involve skin of nipple
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Most common type of invasive carcinoma in breast |
Invasive ductal carcinoma |
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How does invasive ductal carcinoma present? |
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Special subtypes of invasive ductal carcinoma |
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Tubular carcinoma |
Characterized by well-differentiated tubules that lack myoepithelial cells; good prognosis |
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Mucinous carcinoma |
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Medullary carcinoma |
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Inflammatory carcinoma |
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Lobular carcinoma in situ (LCIS) |
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Invasive lobular carcinoma |
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Most important vs. most useful prognostic factors in breast cancer
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HER2/neu |
This gene is associated with response to transtuzumab (Herceptin), a designer antibody directed against the HER2 receptor; HER2/neu is a growth factor receptor present on the cell surface |
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Which mutation is associated with breast and ovarian cancers? |
BRCA1 |
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Which mutation is associated with male breast cancer? |
BRCA2 |
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Male breast cancer |
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