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6 Cards in this Set
- Front
- Back
Antifibrinolytic Drugs |
•Prevent the lysis of fibrin •Result in promoting clot formation •Used for prevention and treatment of excessive bleeding resulting from hyperfibrinolysis or surgical complications |
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Antifibrinolytic drugs |
•aminocaproic acid (Amicar) ~tranexamic acid •desmopressin (DDAVP) ➢Similar to ADH ➢Also used in the treatment of diabetes insipidus |
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Antifibrinolytic Drugs: indications |
-Desmopressin may be used to treat patient who has hemophilia A or type I Von Willebrand disease
-as stated earlier recombinant factors VII, VIII, and IX are used to treat hemophilia or to stop bleeding from excessive warfarin therapy |
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Antifibrinolytic drugs: contraindication |
-Known drug allergy -disseminated intravascular coagulation
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Antifibrinolytic drugs: adverse effects |
-acute cerebrovascular thrombosis -acute MI
- •Uncommon and mild •Rare reports of thrombotic events •Others include: ➢Dysrhythmia, orthostatic hypotension, bradycardia, headache, dizziness, fatigue, nausea, vomiting, abdominal cramps, diarrhea, others |
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Antifibrinolytic drugs: Interactions |
-Estrogens or oral contraceptives used with aminoparodic acid or tranexamic acid, resulting in increased coagulation
-monitor des oppression when given with lithium
-chlorpromazine and fludrocortisone may lead to edema
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