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62 Cards in this Set
- Front
- Back
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which of the biochemi processes below is promoted by insulin
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uptake of glucose by cells
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which of the following hormones promotes hyper-glycemia
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growth hormones
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which of the following is characteristics of type I d. mellitus
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requires insulin replacement to prevent ketosis
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which of the following is characteristics of type 2 d. mellitus
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hyperglycemia is often controlled without insulin replacement
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which of the following results falls within the diagnostic criteria for d. mellitus
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random plasma glucose of 250 mg/dL and presence of symptoms
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select the appropriate rr for fasting blood glucose
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65 - 99 mg/dL or
3.61 - 5.50 mmol/L |
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when preparing patient for an oral glucose tolerance test, which of the following condtx will lead to erroneous results
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cab intake is restricted to below 150g/day for 3 days prior to the test
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which of the following 2 hr glucose challenge results would be classified as impaired glucose tolerance (IGT) two hour serum glucose
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150 mg/dL
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which statement regarding gestational diabetes mellitus (GDM) is correct
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it is defined as glucose intolerance originating during pregnancy
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which of the following finding is characteristics of all forms of clinical hypo-glycemia
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neurologicopenic symptoms at the time of low blood glucose values
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which statement regarding glycated (glycosylated) HGB (GHGB) is true
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it reflects the extend of glucose regulation in the 8 to 12 week interval prior to sampling
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what is the american diabetes ass recommend cutoff value for adequate control of blood glucose as measured by glycated HGN
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7%
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which statement regarding mz of G-HGB (glysocated HGB) is true
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levels do not need to be measured using fasting
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according to american diabetes ass criteria, which result is consistent w/ a di of impaired fasting glucose
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117 mg/dL (anything over >100 but <126)
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what is the recommended cutoff for early detection of chronic kidney disease in diabetics using the test for microaluminuria
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>30 mg/g creatinine but <300 mg/g
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which testing situation is appropriate for the use of POC whole blood glucose methods
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monitoring the blood glucose control in types I and 2 diabetes
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which of the following is the reference method of mz serum glucose
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hexokinase
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polarographic method for glucose analysis is based upon which principal of mz
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the rate of O2 depletion
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select the emz that is most sp for B-D glucose
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glucose oxidase
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select the coupling emz used in the hexokinase method for glucose
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G6PD
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which glucose method is subject to falsely lo results cause by ascorbate
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trinder glucose oxidase
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which of the following is a potential SOE in the hexokinase method
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hemolysis
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which statement about glucose is CSF is correct
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levels below 40 mg/dL occur is septic meningitis, cancer, & mx scelerosis
- csf glucose level is 50 - 60% of plasma glucose |
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what does a high glucose value mean in a CSF sample
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a reflection of hyperglycemia & not CNS disease
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in peroxidase coupled glucose methods, which reagent complexes w/ the chromogen
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phenol
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which of the following is classified as a mucopolysaccharide storage disease
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Hurler's syndrome
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identity the emz defncy responsible for type I glycogen storage disease (von Gierke's disease)
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glucose 6 phophatase
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which of the following abn lab results is found in von Gierke disease
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hyperlipidemia
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the D-xylose absorption test is used for diff di of which two disease
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pancreatic insufficiency from malabsorption
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which of the statement below about carb intolerance is true
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galactosemia results from defncy of galactose-1-phosphate (galactose-1-PO4) uridine
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which statement below regarding iron metabolism is correct
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the daily req is higher for pregnant & menstruating woman
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which of the processes below occurs wen iron is in the oxidized Fe 3+ state
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binding to transferring + incorporation into ferritin
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which of the following is ass w/ low serum iron values & high TIBC
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anemia ass w/ pregnancy
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which condtx is ass w/ the lowest saturation of transferrin
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iron defncy anemia
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which condtx is most ass w/ HIGH serum iron levels
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noniron defncy anemias
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which of the following is likely to occur first in iron defncy anemia
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decrease serum ferritin
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which formula produces the best est of serum transferrin
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TIBC x 0.70 = transferrin in mg/d:
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which statement regarding the di of iron defncy is correct
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a low serum ferritin level is di of iron denfcy
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which statement about iron method is true
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colorimetric methods mz binding Fe2+ to a ligand such as ferrozine
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which statement below regarding TIBC assay is true
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all TIBC method req addition of excess iron to saturated transferrin
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which statement is true in regards to metabolism of bili
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it is produced from destruction of RBCS
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bili is transported from reticuloendothelia cells to the liver by
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albumin
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in the liver, bili is conjugated by addition of
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glucuronyl groups
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which emz is responsible for the conjugation of bili
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uridine disphophse (UDP) glucuronyl transferase
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the term delta (snake character) bilirubin refers to
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bili tightly bound to albumin
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HPLC separates bili into 4 fractions what are they
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a = unconjugated
b = monoglucuronide gamma = (y) diglucuronide delta = irreversibly albumin bound |
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which of the following processes is part of the normal metabolism of bili
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methene bridges of bili are reduced by intestinal bacteria forming urobilinogens
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which of the following is a characteristics of conjugated bili
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it is water soluble
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which of the statement regarding urobilinogen is true
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it is formed in the intestine by bact reduction of bili
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which statement regarding bili metabolism is true
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bili undergoes a rapid photo oxidation when exposed to daylight
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which condtx is cause by defnt secretion of bili into the bili canaliculi
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Dubin Johnson syndrome
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in hepatitis the rise in serum conjugated bili can be caused by
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failure of the entereohepatic circulation
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which of the following is characteristics of obstructive jaundice
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the ratio of direct to total bili is greater than 1:2
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which of the following would cause an INCREASE in only the uncojugated bili
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hemolytic anemia
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which form of hyperbilirubinemia is caused by an inherited absence of UDP glyucuronyl transferease
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Crigler Najjar syndrom
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which statement regarding total & direct bili level is true
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total bili levels is less sensitive & specific marker of liver disease than the direct level
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which statement best characterize serum bili levels in the first weeks following delivery
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jaundice is usually first seen 48-72 hours postpartum in neonatal hyperbilirubinemia
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a lab mz total bili by the Jendrassik Gfor bili method w/ sample blanking. what would be the effect of moderate hemolysis on the test results
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falsely low due to inhibition of the diazo ration by HGB
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which reagent is used for Jendrasski Grof method to solublize unconjugated bili
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caffeineeeeee
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which statement about colormetric bili method is true
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most method are based upon rtx w/ diazotized sulfanilic acid
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which statement regarding the mz of bili by the Jendrassik Grof method is correct
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Fehling reagent is added after diazo reaction to form a BLUE azobilirubin pigment
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a neonatal bili assay performed at the nursery by bichromatic direct spectrophotometry is 4.0 mg/dL. four hours later, a second sample assay for total bili by the JG method gives a result of 3.0 mg/dL, both sample are reported to be hemolyzed, what is the most likely explanation of these results
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HGB interference in the second assay
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