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12 Cards in this Set

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BUN Creatinine Ratio

BUN/Creatinine




Increase: Prerenal or Postrenal Azotemia

Creatinine Clearance

(urine creatinine X urine mL per 24 hr / 1440)


_____________________________________________


(plasma creatinine)




X (1.73)


________




(Body surface area)




Decrease: Renal Disease

Free Thyroxine Index

THBR X T4




Estimation of free T4




Increase: Hyperthyroidism




Decrease: Hypothyroidism

LDL Cholesterol

Total Cholesterol - (triglycerides/5 +HDL Cholesterol)




Increase: Risk of Coronary Artery Disease

Anion Gap Ratio

(Albumin)


_________________________


(Total Protein -Albumin)




Reversed A:G ratio seen with multiple myeloma and liver disease.

Anion Gap

(Na + K) - (Cl + CO2)


or


Na - (Cl + CO2)




Difference b/w unmeasured anions and cations




Increase: Renal Failure, Diabetic Acidosis, Drugs

Calculated Osmolality

1.86 Na + (glucose/18) + (BUN/2.8) + 9


or


2 Na + (glucose/20) + (BUN/3)




Increase: Dehydration, Uremia, Uncontrolled Diabetes, Alcohol or Salicylate Intoxication




Decrease: Excessive water intake

Trough

Lowest concentration of drug measured in blood. Reached just before next dose.

Peak

Highest concentration of drug measured in blood. Drawn immediately upon achievement of steady state.

Steady State

Amount of drug absorbed and distributed equals amount of drug metabolized and excreted. Usually reached after 5-7 half-lives.

Half-Life

Time required for concentration of drug to be decreased by half.

Pharmacokinetics

Rates of absorption, distribution, biotransformation, and excretion.