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42 Cards in this Set
- Front
- Back
What three things is chronic liver injury usually associated with? (think process, response to process, and final response of process). What is the liver's way of scarring? (term)
What is a common cause of chronic liver injury? |
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Chronic viral hepatitis usually causes a |
Chronic viral hepatitis usually causes a |
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Where is the localization of most of the inflammatory infiltrate? |
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In some cases of hepatitis B, The presence of virions in the |
In some cases of hepatitis B, The presence of virions in the |
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In some cases of chronic hepatitis This is _____ hepatitis. It has also been |
In some cases of chronic hepatitis This is interface hepatitis. It has also been |
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What type of hepatitis (infection type)? |
Interface hepatitis effacing the limiting plate |
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Can you tell where the limiting plate is? |
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It was thought for many years that |
It was thought for many years that |
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When quantitative blood testing for |
When quantitative blood testing for |
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Interface depends on viral activity at time of biopsy. |
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Does the finding of interface hepatitis have any predictive value regarding the evolution of the disease?
What does it reflect? |
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With acute injury, mature |
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The key players in the hepatic |
The key players in the hepatic |
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The initial deposition of fibrous In chronic hepatitis and this is described as |
The initial deposition of fibrous In chronic hepatitis and this is described as |
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What type of expansion? |
Fibrous portal (Trichrome stain) |
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In cases where the chronic injury This is a frequent change in and this is described as |
In cases where the chronic injury This is a frequent change in and this is described as |
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What type of sclerosis? |
Central sclerosis |
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With ongoing chronic injury, the Eventually, the fibrosis in one part This is _____ fibrosis, |
With ongoing chronic injury, the Eventually, the fibrosis in one part This is bridging fibrosis, |
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What type of fibrosis? |
Bridging |
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Timing of fibrosis (early or late)? |
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More advanced fibrosis |
Yep |
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What type of fibrosis? |
Bridging fibrosis |
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What does the collagen type in the space of Disse change to with chronic injury? |
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What is really the only thing that the stellate cells do normally?
With chronic injury, what activates stellate cells to make myofibroblasts => collagen? |
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Activated stellate cells produce _____ factors, chemokines and
TNF is considered the major cytokine effector of liver injury
Like fibrosis anywhere, in the liver, fibrosis is a _____ process.
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Activated stellate cells produce growth factors, chemokines and
TNF is considered the major cytokine effector of liver injury
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Eventually, the fibrosing repair |
Eventually, the fibrosing repair |
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What is this end-stage of liver disease? |
Cirrhosis |
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What can you see here? |
The regenerative nodules of cirrhosis. |
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What is the nodule surrounded by? |
Regenerative nodule surrounded by fibrous tissue |
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You can think of regenerative |
You can think of regenerative |
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What are the manifestations of cirrhosis? Alk phos? AST and ALT? Bilirubin? Serum albumin Prothrombin time?
What is the most important manifestation of cirrhosis? |
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What are these lesions? |
Spider angiomas (spider telangiectasias, spide nevi, or just spiders) |
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Spider angiomas:
They are vascular lesions consisting of a central arteriole surrounded by many smaller vessels, most frequent on the trunk, ___ and arms. |
They are vascular lesions consisting of a central arteriole surrounded by many smaller vessels, most frequent on the trunk, face and arms. |
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What two things is Dupuytren contracture (palmar fibromatosis) associated with? |
Diabetes mellitus and cirrhosis (particularly alcoholic) |
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What are the four most common causes of cirrhosis?
What percent of alcoholics get cirrhosis? |
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Draw the pathways of hepatitis C |
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Non-Alcoholic Steatohepatitis (NASH) Liver disease that looks like _____ Associated with elevated levels of |
Non-Alcoholic Steatohepatitis (NASH) Liver disease that looks like alcoholic Associated with elevated levels of |