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41 Cards in this Set
- Front
- Back
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What diseases are associated with HLA-B27?
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-Ankylosing spondylitis
-Reiter's |
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What HLA antigens are associated with diabetes?
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DR4 and DR6
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What HLA antigens are associated with rheumatoid arthritis?
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DR1 and DR4
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Which HLA is associated multiple sclerosis?
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DR3
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Which HLA is associated with Grave's disease?
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DR3
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What autoantibodies are associated with lupus?
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1. ANA
2. anti-DNA 3. Sm 4. SSA |
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What autoantibodies are associated with drug induced lupus?
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anti-histone
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What autoantibodies are associated with CNS lupus?
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anti-ribosomal P
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What drugs can cause SLE?
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-Procainamide
-Hydralazine |
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What happens to the CD4:CD8 ratio in rheumatoid arthritis?
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drops to < 1
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What is rheumatoid factor?
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- Anti-IgG (Fc regions)
- usually IgM, may be any isotype - may be located in synovium and cartilage - may form cryoglobulins -may be monoclonal or polyclonal - will form immune complexes |
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What marker may have higher sensitivity and specificty in juvenile RA?
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anti-CCP (cyclin citrullinated peptide)
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What are the markers for mixed connective tissue disease (MCTD)?
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- anti-RNP
- speckled ANA |
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What is the incidence and symptoms of MCTD?
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- 80% female
- presents at any age Presentation: 1. Raynaud's phenomenon and swollen digits 2. pulmonary disease 3. polyarthralgias |
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What is the pathology of scleroderma and what are the markers?
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Pathology:
-collagen deposition -immunoglobulin - increased Th activity - increased lymphokines - increased B cell activity Diagnosis: - anti-centromere (CREST) - nucleolar (anti-RNA) - ANA |
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What markers are found in Sjogrens?
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- ANA
- SSA (Ro) - SSB (La) |
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What medications are associated with drug induced ANA positivity and Lupus like disease?
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Procainamide
Hydralazine Quinidine Methyldopa Isoniazid Chlorpromazine Minocycline |
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What medications are strongly impicated with drug induced ANA positivity and Lupus like disease?
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Phenytoin
Mephenytoin Penicillamine Carbamazepine |
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What ANA patterns can cause a speckled pattern?
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SS-A (Ro)
SS-B (La) Smith DNA Topoisomerase I (Scl-70) U1-RNP PCNA |
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What ANA patterns can cause a homogenous pattern?
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DNA
histones |
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What ANA patterns can cause a nucleolar pattern?
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RNA polymerase I
PM-Scl U3-RNP |
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What ANA patterns can cause a anti-centromeric pattern?
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CENP-B
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What ANA patterns can cause a peripheral rim pattern?
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dsDNA
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What diseases can cause a speckled ANA pattern?
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SLE
MCTD Sjogren's Scleroderma |
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What diseases can cause a homogenous ANA pattern?
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SLE
drug-induced Lupus |
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What diseases can cause a nuceolar ANA pattern?
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Scleroderma
Polymyositis/Scleroderma overlap |
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What diseases can cause an anti-centromeric ANA pattern?
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CREST
Raynaud's |
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What diseases can cause a peripheral (rim) ANA pattern?
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SLE
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What diseases can cause a speckled ANA pattern?
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SLE
MCTD Sjogren's Scleroderma |
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What diseases can cause a homogenous ANA pattern?
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SLE
drug-induced Lupus |
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What diseases can cause a nuceolar ANA pattern?
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Scleroderma
Polymyositis/Scleroderma overlap |
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What diseases can cause an anti-centromeric ANA pattern?
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CREST
Raynaud's |
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What diseases can cause a peripheral (rim) ANA pattern?
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SLE
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What is associated with anti-smooth muscle (SMA)?
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Autoimmune hepatitis
-followup with SMA specific test (IIF with rat stomach for detection of smooth muscle antibodies) |
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What is associated with an anti-ribosomal pattern?
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SLE with neuropsychiatric symptoms
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What is associated with anti-golgi pattern?
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Non-specific
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What is associated with anti-jo-1?
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Polymyosistis/Dermatomyositis
-followup with Jo-1 specific testing |
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What is associated with anti-mitotic spindle pattern?
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SLE
Sjogren's |
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What is associated with anti-mitochondrial antibody (AMA)
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PBC
-followup with IIF with rat proximal tubule for detection of antimitochondrial antibodies |
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What antibodies are associated with neonatal lupus?
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anti-Ro (SSA)
anti-La (SSB) |
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What are the clinical symptoms of neonatal lupus
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-Complete heart block (third degree AV block)
-Mild rash |
