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113 Cards in this Set

  • Front
  • Back

What is the difference between RCT and Quasi studies?

RCT can show causality or confidence in study because of lack of bias
Quasi is an experiment/ intentional study to take

What is a type 1 error?

It is a false positive. Where you reject the null hypothesis, when it is actually true. You observe a relation when there is none

What is a type 2 error?

It is a false negative. You accept the null hypothesis when you shouldnt have. You do not see a relation when there is one.


What is a solution to fix a type 2 error?

Increase sample size

Can range be calculated for the whole group or study or population?

No. It is too large and must be of a smaller category

Is the mean susceptible to the median?

The mean is sensitive to outliers and is not resistant to the median

Is the median resistant to outliers?

Yes, the median is resistant to outliers

What does this mean;

Mean < median

Negative

Mean > median

Positive

If there is a peak at the beginning of a graph, is it a negative or positive outcome?

Positive

If there is a peak at the end of a graph, is it a negative or positive outcome?

Negative

What is the mean?

The average of all the numbers divided

What is the median?

The 'middle' value in the list of numbers

What is the mode?

The number that occurs most often

What is reliability?

Consistency and repeatability - ie same results, over and over

What is validity?

Whether the construct you are using really measures what you are using it to measure

How do you interpret a p value of P >0.05?

The result is significant and you accept the null hypothesis

What are descriptive study questions?

Descriptive describes the nature of the study

What are relational study questions?

Relational are questions that question the relationship between two variables

What are casual questions?

Casual questions refer to how one variable will affect another

What are independent and dependent variables?

- The independent variable is what is changed. It is the exposure or the intervention
- The dependent variable is the variable changes because of the independent variable. Essentially it is the outcome

What is null hypothesis and what is the hypothesis?

- The null hypothesis is a statement that declares that the variables will not have a relationship. Eg: 'it does not', 'there will not', etc
- The hypothesis is a statement that declares that there will be a relationship between the variables. Eg: 'if, then',

What are the probability methods of sampling?

- Simple random: Every unit has an equal chance of selection
- Stratified random: Units divided into clusters and a % of each cluster is chosen
- Cluster: Units divided into clusters and all of a few selected clusters are chosen
- Systematic random: Every 'X' unit is chosen
- Multi stage: A combination of above stages

What are the non-probability methods of sampling?

- Convenient: Whichever units are convenient
- Purposive: Specific units sought out
- Modal instance: Most frequently occuring unit
- Exerpt: High quality units sampled
- Diversity: Wide range of units sampled
- Snowball: More units are added as the study progresses

What is a systematic error?

There is a bias in measurement which will affect the mean

What is a random error?

Is a human error which will affect the standard deviation

What is a measurement?

The attribution of quantities and qualities to characteristics of people, objects or events

What is measurement a key process of?

Quantitative research

What is External validity?

How the findings of the study can be generalised to other studies

What is internal validity?

Validity of the study design characteristics

What is the difference between objective and subjective measurements?

Objective is physical quantities or qualities
Subjective is human ratings or judgements

What is the formula for proper measurement?

Observed value = True value +/- measurement error

What are the 4 aspects of a good measurement?

1. Well defined
2. Same information creates same answer
3. Different information creates different answer
4. Information is understood

What is nominal, ordinal and interval & ratio data?

Nominal: Categorical information. Where you can not get an average
Ordinal: Intervals between each unit are not the same
Interval & ratio: Intervals between each unit are the same

What is the difference between experimental and observational study designs?

Experimental: Scientific interventions = holds high external validity
Observational: No intervention

What are 5 quantitative study designs?

1. Ecological
2. Cross sectional
3. Cohort
4. Case control
5. Intervention

What are 3 qualitative study designs?

1. Focus groups
2. Interviews
3. Questionnaires

What is a Cochrane review?

It is a systematic review of multiple pooled studies

What are the 4 aspects of ethics?

1. Beneficence - Benefit to patient
2. Non Maleficent - Do no harm
3. Justice - fairness
4. Autonomy - Respect for rights

What are Ethics?

Guided notation for what is morally acceptable/unacceptable

What does an ethics committee review?

1. Evaluates risks and benefits
2. Evaluates value of research
3. Evaluates biases of study

What are descriptive statistics of measurement?

Mode, mean, median and standard deviation

When is a confidence interval significant?

What it does not contain "1". Eg: a 95% confidence rating would be 0.05

What is the formula for and odds ratio?

( A / C ) / ( B / D )

What is the formula for relative risk?

( A / A + B ) / ( C / C + D )

What does the P-value infer about the null hypothesis?

<0.05 = Rejection of the null hypothesis
>0.05 = Acceptance of the null hypothesis

What 3 factors are in the Evidence-base practice model?

1. Patient values
2. Clinical Expertise
3. External evidence

What are the 5 levels of evidence?

1. Systematic review of RCT
2. Random control trials
3. Quasi controlled trial
4. Case control and cohort group (observational studies)
5. Case studies, cross-sectional, Anecdotes

What is the difference between RCT's and Quasi controlled trials?

Quasi controlled trials are not random

Strengths of case control studies are:

Less expensive than cohort studies
Suitable for rare exposures
No attrition problems

The lower the P value is, the ____ likely that the results are due to chance

Less

When looking at Relative Risk and Confidence Intervals, if you are provided with the following: RR= 1.7 (0.8, 2.2), you could interpret this as a person is 1.7 times ______ likely to develop a condition. This is known as _______ association. When an Relative Risk is deemed to have a ______ factor, the RR is typically ______ than the null value

A - Protective
B - Positive
C - More
D - Negative
E - Less

C - More
B - Positive
A - Protective
E - Less

Which of the following is true about correlation statistics?
1. r = -0.50 is weaker than a correlation r = 0.30
2. r = 0.50 is stronger than a correlation r = -0.50
3. r = -0.30 is stronger than a correlation r = 0.25
4. r = -0.30 is stronger than a correlation r = 0.30

3. -0.30 is stronger than a correlation of 0.25

What type of data is the mean significant for?

Interval / ratio data

What is it meant when the term Theoretical Population is mentioned?

Who you want to generalise the study findings to

What is the sample frame?

Accessible population to draw the sample from

What are the 4 sizes of study populations?

1. Theoretical population
2. Study population
3. Sample frame
4. Sample

How can a type II error can be rectified?

By changing the sample size

What are the different ways to rate an R correlation coefficient?

0.01 - 0.25 = weak
0.25 - 0.50 = weak to moderate
0.50 - 0.75 = moderate to strong
0.75 - 1.0 = strong

What are the 3 Qualitative study designs

1. Focus groups
2. Interviews
3. Questionnaires

What do Cohort studies cover?

Retrospective and prospective time frames


What can observational studies infer and what cant they infer?

They can infer correlation but cannot infer causation

What do Odds Ratio's of <1 and >1 mean?

<1 = Exposure decreases the odds of having an outcome
>1 = Exposure increases the odds of having an outcome

How do you describe an Odds Ratio of 1.7?

It is 1.7 times more likely to have that outcome

How would you describe an Odds Ratio of 0.69?

It is 31% less likely to have that outcome

What is the 4 dog defense experiment?

1. "My dog does not bite"
2. "My dog bites, but not you"
3. "My dog did bite but it didnt hurt"
4. "My dog bit and it hurt but its not my fault, its your fault"

What advantages can case studies have over study designs?

The case will be more personal, rather than direct data

How many phases do clinical trials go through?

Three

What is herd immunity?

It is a form of indirect protection from infectious disease that occurs when a large percentage of a population has become immune to an infection, thereby providing a measure of protection for individuals who are not immune

What are the 3 sections of the Hippocratic Oath?

1. All actions must benefit the patient
2. Patient confidentiality must always be present
3. Doctors must not seek self-benefit

What is the fundamental Principle of the Nuremburg Code?

That there must be voluntary consent

What is deductive and inductive reasoning?

Deductive: Many ideas are funneled down into simple statements

Inductive: Simple statements create larger concepts

What does a prospective Cohort design measure?

Levels of exposure

What is grounded theory?

A study with no preconceived ideas. The data flow, influences the direction of the study

What is Ethnography?

It is a study of cultural differences

What is Phenomenology research and how is it conducted?

It is the study of lived experience vs representative experience and is conducted through observation

When is a P value of >0.05 good?

When it is the baseline demographic: >0.05 represents between-group differences.

Baseline demographics are good so we can know if any differences occur because of the study and not extraneous variables

What are confounding variables?

Variables outside the study that can effect the results of the study

What study design can effectively show cause and effect?

Randomly Controlled Trials (RCT's)

Whats the key difference between a research question and a hypothesis?

RQ is a question. The hypothesis is a statment

What is the casual variable and which is the affected variable in:

X causes Y

X is the casual
Y is the affected

What 2 problems must causal studies resolve?

1 Extraneous variables: variables outside the study affecting the results of the study
2. Directionality problem: whether or not the cause truly prefaced the effect

What problem does manipulating the causal variable resolve?

Directionality problem

What problem does random assignment control?

Extraneous variable problem

What is operationalization?

It is the process of converting theoretical ideas into a tightly defined & quantifiable statement

What is an operational definition?

How the researcher chooses to study a variable

What are the 4 desirable properties of measurement?

1. Reliability
2. Validity
3. Practicality
4. Applicability

What are the 3 forms of reliability testing?

1. Test-retest: administering the same test twice
2. Inter-observer: having multiple clinicians assess patient
3. Internal consistency: How each unit within the study correlates with one another

What does systematic error and random error affect?

Systematic error affects the mean
Random error affects the spread

What is PICO and what is it useful for?

Population: information regarding the population
Intervention: treatment, diagnosis, prognosis
Comparison: comparing interventions
Outcome: Desired outcome

They help structure a solid research question

What does levels of evidence mean?

To what degree information can be trusted

What are the pros and cons of a systematic review?

Pros:
- Resolves contradictory findings
- Easy to interpret
- Minimal bias
- Low confounding variables
Cons:
Can gloss over individual flaws

What sampling frame difference is there between probability and non-probability data?

Probability: Accurate
Non-probability: Inaccurate sample frame

What sampling error difference is there between probability and non-probability?

Probability: Can not be calculated
Non-probability: Can be calculated

What sampling size difference is there between probability and and non-probability data?

Probability: Determined by sample theory
Non-probability: Matter of convenience

What level of generalizability difference is there between probability and non-probability?

Probability: Representative
Non-probability: Illustrative

What are different kinds of validity?

Face/content: Difficult to find external measures to correlate with the test
Sensitivity/specificity: Proportion of people who test positive/negative
Predictive: Ability to test predictive values of research

What are some ways to reduce measurement error?

- Repeat several times
- Measure under controlled conditions
- Calibrate equipment
- Know error of the tool
- Use same person to measure

What is a Relative Risk and Odds ratio in terms?

Relative risk: Ratio of probability of an event occurring in an exposed group, compared to an unexposed group
Odds ratio: Measure of association between exposure and outcome

What is analysis of variance?

Test that compares the average scores between 3 or more outcomes

What is the difference between single blind and double blind studies?

Single blind: Participant doesnt know what group they are in
Double blind: When neither researcher nor participant knows what group they are in

What do single and double blind studies help to reduce?

Single: Reduces personal bias
Double: Reduces researcher bias

What kind of study is a Epidemiological study?

Observational

What is the main issue with Cohort studies?

Attrition

What is Progressing focusing?

Changing the research question in light of the data

What is the difference between a positive and a negative association?

Positive: Exposure increases offs of outcome
Negative: Exposure does not increase odds of outcome

When relative risk has a Protective Exposure, what does this mean?

The relative risk is generally less than the null value

What are the 3 percentage levels of Standard Deviation that are used on a non-skewed graph?

SD = 68%
SD2 = 95%
SD3 = 99%

If the mean of a non-skewed graph is 100 and the SD is 95 and 105. What is the SD2 and SD3?

SD2 = 90 and 110
SD3 = 85 and 115

If the mean of a non-skewed graph is 350 and the SD is 325 and 375. What is the SD2 and SD3?

SD2 = 300 and 400
SD3 = 275 and 425

In a study examining the impact of smoking, upon rates of cancer. What is the independent variable and dependent variable?

Smoking = Independent variable
Cancer = Dependent variable

As the number of sleeping hours decrease, the mental alertness also decreases. This is known as a:
1. A positive correlation
2. A negative correlation
3. A normal distribution
4. An inverse correlation

1. A positive correlation

As sleeping hours increase, so does mental alertness. Showing a graph in a positive direction upwards

What does a correlation provide and what number is it always show to be in between?

It provides direction and strength. Correlation is always between -1 and +1