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13 Cards in this Set
- Front
- Back
How does ESRD affect the endocrine system?
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Feedback mech's
Hormone Prod Hormone Transport Hormone Metabolism and Elimination |
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What endocrine organs are affected by CKD
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Pituitary
Gonads Diabetes Bones (metabolic bone disease) |
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CKD and Growth?
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-GH is elevated
-Growth is retarded in kids w/ CKD despite normal GH levels -Rx w/ GH restores growth velocity -Transplant does not always restore growth velocity |
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PRL and CKD?
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PRL is elevated (dec clearance)
Gynecomastia Impotence Amenorrhea |
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Male Gonadal Hormones and CKD?
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Testosterone Decreases
LH Inc FSH Inc |
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Result of male gonadal dysfxn from CKD?
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Dec Libido
Impotence Testicular Atrophy Infetility |
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Female Gonadal Hormones and CKD?
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Inc LH:FSH ratio
Loss of mid-cycle LH and FSH surges |
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Sx's of CKD related to gonadal hormones?
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Dec Libido
Amenorrhea Infertility |
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Diabetes and CKD?
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reduced insulin clearance leading to inc risk of hypoglycemic episodes
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Why do you get HypoCa w/ CKD?
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Inc Phosphate Retention (binds to Ca)
Altered Vit D metabolism (dec 1,25) Skeletal Resistance to PTH |
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Three Components of Renal HyperPTH?
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Hypocalcemia
Altered Ca-regulated PTH secretion Reduced Clearance of PTH |
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Long-term affect of Renal HyperPTH on parathyroid glands?
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After being "on" for so long they can't turn "off" = Tertiary HyperPTH
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Sx's of Tertiary HyperPTH?
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Pseudoclubbing...i.e. the tips erode away
Calcifalaxis Kyphosis Sternal Buckling |