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16 Cards in this Set
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- Back
- 3rd side (hint)
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BACILLUS ANTHRASIS ( zoonotic) abattoir worker
Wool sorters dz /hide porters dz |
EXOTOXIN is virulence factor not capsule
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Category A bioterrorism agent
Aerobic capsulated non motile habitat : soil herbivore> carnivore animals mammals & guinea pigs susceptible INSECT bite contact with sick animals ingestion inhalation |
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in 95% D/d pseudomonas ( etchyma granulosum : black eschar in HIV pts) start as macule -papule- vesicle-malignant pustule (Painless) |
Diagnosis: MC fayden rxn - bipolar staining , end to end appearance |
5% have pulmonary anthrax : wool sorters disease - hemorrhagic pneumonia |
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Medusa head colonies
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42° melting pt
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Motile
Non capsulated |
cause opportunistic infections: endocarditis meningitis
bacteremia crepitant cellulitis LRTIs |
by fried rice
pasta cheese potato |
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2 toxins:
Emetic toxin- short IP heat stable symptoms after 1-6 hrs only vomiting & abdominal cramps (characteristic feature) NO fever (aiims) by Rice potato cheese pasta Enterotoxin- long IP heat labile symptoms after 10-12 hrs abdominal cramps (characteristic feature) watery diarrhea nausea by meat dairy products vegetables sea food |
culture: MYPA
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LISTERIA Monocytogenes :
camp+ tumbling motility refrigerated cheese |
virulence: by ability to replicate in cytoplasm (phagolysosome) avoids humoral immune system
lysteriolysin >IFN- gamma :Th1 response- granuloma Granulomatosis infantiseptica Ring enhancing lesions CNS infections |
ANTON test + : severe kerato conjunctivitis appear after 24 hr in animal eye
only g+ with LPS |
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CLOSTRIDIUM (subterminal spore)
only those strains of clostridium associated with food poisoning have heat resistant spores |
mc spore forming g+ rods
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obligate anaerobe d/t lack of
-SOD -Catalase -Peroxidase |
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Clostridium intubated in GASPAK
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Most species of clostridium obligate anaerobes that is their spores do not generate and growth does not normally proceed unless a suitable low redox potential exists :)
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old method: Mc intosh fildes jar
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C.tetani
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prevention: 3 1°doses @1,6,10,wk+ 1 booster dose
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C.botulinum
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" HIGHLY LETHAL "
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canned food
adults: microbial flora gives competitive inhibition, so spores don't germinate children : no microbial flora (FLOPPY CHILD) botox : inhibit acetylcholine |
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C.PERFRINGENS
target hemolysis |
typeA:food poisoning & gas gangrene
type B:Enteritis necroticans |
alpha toxin: lecithinase= pigbel= drambrand
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C.perfringens
indole - MR+ VP- nitrate reduction test+ |
"opalescence on one side"
[ because alpha toxin splits lecithin into phosphorylcholine and diacyl glycerol in presence of calcium and magnesium ions ] And other side is not opalescent because it has no anti toxin |
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C.DIFFICILE
pseudomembranous colitis d/t clindamycin mc antibiotic used : cephalosporin III |
Exotoxin: A- active enterotoxin
B- GTP binding cytotoxic toxin detection: ELISA |
DOC: 1st metronidazole
2nd vanconycin |
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Corynebacterium diptheriae
metachromatic granules |
Stains:
Albert neisser ponder |
Toxigenicity test: in vitro : Elek gel ppt& Shick skin test
in vivo: s/c - MLD I/d - MRD |
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Campylobacter jejuni= bacterial enteroritis
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IP: 1-7 days
abdo pain diarrhea severe watery diarrhea lead to prostration leucocytes in faces |
consumption of meat directly or cross contamination with other food
jejunum & ileum [INVASIVE] mesenteric LNs sequelae: -GBS S° -Reiters S° |
