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49 Cards in this Set
- Front
- Back
Blood constituants (blood & plasma) are:
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45% blood
55% plasma |
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In myelopoiesis, which is the first stage to have non-specific granules?
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promyelocyte
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Where is EPO hormone created?
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kidney
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Which site is used most for adult BM biopsy?
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illian crest
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Name the order of granulocytopoiesis:
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myeloblast
promyelocyte myelocyte metamyelocyte band |
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N:C changes how as cell matures?
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ratio decreases (nucleus gets smaller)
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Does the hematology lab perform electrolyte studies?
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No
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Histocyte macrophages are located where?
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connective tissue
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In the fetus, the primary site of hematopoiesis is:
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liver
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Bands contain all ______ granules
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specific
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T cells mature in teh:
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thymus
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what are the 3 stromal elements of the hematopoeitic microenvironment?
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Fibroblasts
Macrophages Adipocytes |
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What is the first cell developed by the fetus?
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RBC
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Macrophages 2 main functions:
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remove debris
APC's |
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BM biopsies from children are taken from:
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tibia
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Which erythroctye metabolic pathway generates ATP via glycolysis?
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Embden-Meyerhof
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What is the last RBC precurser stage is the last to undergo mitosis?
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polychromatophilic normoblast
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At high altitude, RBC's ____________
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increase
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Methgb contains:
The methgb reductase pathway is to maintain the __ form of Fe: |
ferric form of iron
the ferrous form of Fe. |
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What are the 3 most important cell areas for RBC survival and function?
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RBC cell membrane
cell metaboilism hgb structure |
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The Rapoport Leubering shunt produces what?
What does this product aid in? |
2,3 DPG
Oxygen delivery to tissues |
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What is teh most abundant of cells in teh PB?
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Neutrophils
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Plasma cells have what physical characteristic?
Reactive Lymphocytes show what smear characteristic? |
perinuclear halo
reactives: hug RBCs |
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Hypersegmented neutrophils are associated with what anemia?
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megaloblastic anemia
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Howell Jolly bodies are made up of:
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DNA
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What protein transfers Fe throughout the body?
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Transferrin
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Megaloblastic anemia is considered a ____ , ___ anemia
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macrocytic, normochromic
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Anisocytosis:
What test measures this? |
size variations
RDW |
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A normal hgb molecule is composed of:
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4 heme and 4 globin chains
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IDA & thallasemmia are considered ___ anemias:
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microcytic
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Chronic Liver Disease & B12 deficiency are considered ___ anemias:
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Macrocytic
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Hypochromic disorders are a qualitative or quantitative defect in hgb synthesis?
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QUANTITATIVE
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Spherocytes have what characteristic?
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no central pallor
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A "shift to the left" in the O curve of hgb is associated with what oxygen state?
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decreased oxygen release
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Acanthrocytes are associated with what cell trauma?
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membrane lipids
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Excessive Fe is called:
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hemochromatosis
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In ACD (anemia of chronic disease), serum Fe and transferrin will report out:
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Decreased serum Fe
Decreased transferrin |
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G6PD deficiency and subsequent hemolysis occur bc of:
What cells are seen with G6PD deficiency? G6PD deficiency is a ___ anemias: |
denatured hgb
Bite cells Normocytic |
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IDA will show increased levels of:
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TIBC
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Lead poisioning will show what inclusions?
What do these represent? |
basophilic stippling - ribosomes
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What inclusion cannot be seen under wrights stain?
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Heinz Bodies
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Ringed sideroblasts are usually due to abnormal :
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heme synthesis
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Where does heme synthesis occur in the cell?
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Mitochondria
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What is the main difference b/w ACD and IDA?
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ACD will have normal ferritin levels
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Low serum Fe will result in what level TIBC?
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Increased
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Sideroblastic Anemia:
Serum Fe levels? |
Increased serum Fe
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Anemia classifications are based on what tests?
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RBC indices
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Define pancytopenia:
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Decrease of all cells
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Which hgb is normal:
Carboxyhgb sulfhgb Deoxyhgb methgb |
Deoxyhgb
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