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21 Cards in this Set
- Front
- Back
What are the primary and secondary lymphoid organs?
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Primary: Thymus, bone marrow
Secondary: Lymph nodes, spleen, MALT, Tonsils |
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What are the functions of primary vs secondary lymphoid tissues?
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Primary= production, differentiation, education
Secondary=Activation of lymphocytes due to antigen |
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Where does hematopoiesis take place in a fetus?
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Yolk sac
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What is the major function of the thymus?
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Education of T cells aka T cell maturation
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What decreases as the size of the thymus decreases over the course of a persons life?
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Decrease in CD4+ cells
Loss of immune protection Loss of immune regulation (Regulatory T cells) |
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How do lymphocytes vs DC's with and antigen enter the lymph node?
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Lymphocytes enter via the HEV's
DC w\ antigen enter via the afferent lymphatic vessel |
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What is the force that drives lymph through the lymphatic system?
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Muscular contraction and one way valves
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Are the lymphatc vessels and systemic circulation 2 seperate networks?
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No they are linked
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What are the 2 functional areas of the spleen and their functions?
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Red pulp- Old RBC destruction via macrophages(phagocyt)
White pulp- Lymphoid tissue |
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Where in white pulp to the 2 types of lymphoid cells reside?
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B cells- follicles
T cells- Periarterial Lymphoid sheath(PALS) |
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When is asplenia a major concern?
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In conditions where the antigen or infection is in circulating in the blood, b\c the blood filters at spleen. Tissue response intact via lymph nodes
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What are the 3 bacteria that are of concern in splenia that were given? Tx?
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Haemophilus influenzae
Streptococcus pneuomonia Nisserria Menigitidis Prophylactic antibiotics Vaccines |
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What are the functions and locations of MALT and other lymphoid associated tissues?
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Defends mucous lined tissues with large population of B cells, macrophages, granulocytes and mast cells
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What is the structural difference between MALT and tonsils?
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non-encapsulated vs partially encapsulated
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What is immune cell trafficking?
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When immune cells are moved via the blood to tissues and back via lymphatics
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What are the 2 components of sucessful cell migration\trafficking?
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Extravasation\ Chemotaxis
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What are the cell adhesion molecules that facilitate extravasation?
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CAMs=Integrins and Selectins
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What are chemokines?
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Chemotactic molecules that guide neutrophills and lymphocytes to place of inflammation
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What are the paths of a lymphocyte through the spleen vs a lymph node?
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Spleen= splenic artery-marginal sinuses- blood stream
Lymph node- HEV- efferent lymphatic vessel- blood at venous angle |
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What is the pathway of recirculation of naive B and T cells?
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Through lymph nodes and spleen
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Contrast the recirculatory pathways of acivated B and T lymphocytes?
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Effector T cells go to site of infection
Memory T go to infection site and B cells remain in lymphoid organs to secrete antibodies, some to bone marrow Memory B recirculate through 2ndary lymphoid tiss |