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25 Cards in this Set
- Front
- Back
(I) Pharmacological effects of Histamine.
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(ii) Histamine Site of action
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(iii) Conditions which cause release Histamine
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• (iv) diagnostic uses of Histamine
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• Allergic rhinitis (common cold)
• Allergic conjunctivitis (pink eye) • Allergic dermatological conditions • Urticaria (hives) • Angioedema (swelling of the skin) • Pruritus (atopic dermatitis, insect bites) • Anaphylactic reactions (severe allergies) • Nausea & vomiting (First generation H1-antihistamines) • Sedation (First generation H1-antihistamines) . |
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Anti histaminergic Rx-s acting at the H1 and h2 receptors
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True antihistamines are only the agents that produce a therapeutic effect that is mediated by negative modulation of histamine receptors (other agents may have antihistaminergic action but are not true antihistamines)
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(iv) diagnostic uses of Histamine
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The term antihistamine only refers to
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H1 receptor antagonists (actually inverse agonists)
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Antihistamines compete with histamine for binding sites at the receptors. Antihistamine cannot
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remove the histamine if it is already bound
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Anti histaminergic Rx-s acting at the H1 and h2 receptors Know pharmacological effects
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Anti histaminergic Rx-s acting at the H1 and h2 receptors Understand mechanisms of action
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Be able to list therapeutic uses of antihistaminergic Rx-s
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Be able to describe side effects and Rx interactions
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Be familiar with the existence of the H3 receptors
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main mechanisms of action of Chromolyn Sodium
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Chromolyn Sodium clinical applications.
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Clinical significance of anti histaminergic Rx-s
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What are Histamines; What causes allergies and what are they,
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History of antihistaminergics
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Classes of antihistaminergics
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Future of anti histaminergic Rx-s and treatment of allergies in general.
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Definition of allergies according to American Academy of Asthma, Allergies, and Immunology.
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Synthesis of Histamine
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Histamine (H1-4) receptors
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Histamine (H1-4) receptors
(I) Location (ii) Type of receptors (iii) Pharmacological effects (iv) Treatment |
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Clinical applications of antihistaminic agents
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