Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
What is the formula for the partition coefficient?
|
P = [drug] <--organic
----------------- [drug] <--aqueous |
|
T/F: Most drugs have a partition coeffeicient
|
True
|
|
Define Partition coefficient
|
A measure of the drugs lipid and water solubility (balanced in most drugs)
|
|
__________ is determine by charges (polarity).
(hydrophilicity, hydrophobicity, lipophilicity or lipophobicity?) |
hydrophilicity
|
|
What are the main two things that effect water solubility?
|
-H bonding capacity
-Ionic character |
|
Compounds with what two atoms have increased solubility?
|
Nitrogen and Oxygen
|
|
_______________ is increased by non-ionizable groups, hydrocarbon chains and ring systems.
(hydrophilicity, hydrophobicity, lipophilicity or lipophobicity?) |
Lipophilicity
|
|
List side groups that can increase lipophilicity.
|
-Non-ionizable groups
-Hydrocarbon chains -Ring systems (ex:benzyne) |