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16 Cards in this Set
- Front
- Back
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what receptor does HIV bind to?
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CD4 + CCR5/CXCR4
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What receptor does EBV bind do?
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CD21 (B lymphocytes)
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What receptor does rabies bind to?
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ACh receptor
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What receptor does Rhinovirus bind to?
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ICAM-1
Respiratory epithelial cells |
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Hepatitis A
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Infectious
Family: Picornavirus RNA, *Naked* capsid Transmission: Fecal-oral Disease: mild acute, not chronic or sequellae Dx: IgM to HAV |
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Hepatitis B
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"Serum"
Family: Hepadnavirus **DNA** (needs reverse transcriptase), Enveloped Dz: acute, can be severe -chronic: 90% of infants -Primary hepatocellular ca. -Cirrhosis Dx: HBsAg, IgM to HBcAg |
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Hepatitis C
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"Post-transfusion"
Family: Flavivirus RNA, Enveloped Dz: 80% become chronic -primary hepatocellular ca. -cirrhosis Dx: Ab to HCV, ELISA |
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Hepatitis D
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"Delta"
Family: Defective Circular RNA, Enveloped Co-infection with HBV: occasionally severe Superinfection with HBV: severe Cirrhosis, fulminant hepatitis Dx: Hep D Ab, HBsAg |
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Hepatitis E
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"Enteric"
Family: Hepevirus RNA, *Naked* Capsid transmission: fecal-oral Severe dz in **pregnant pts** Dx: Ab to HEV, ELISA |
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HBsAg
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Antigen found on surface of HBV
Positive during acute disease If present >6mo indicates carrier state |
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HBsAb
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Antibody to HBsAg
provides immunity to hep B -prior infection or immunization |
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HBcAg
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Antigen associated with core of HBV
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HBcAb
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antibody to HBcAg
Positive during window phase IgM to HBcAb is an indicator of recent disease |
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HBeAg
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Important indicator of transmissibility
a 2nd, different antigenic determinant on the HBV core |
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HBeAb
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Antibody to e antigen
indicates LOW transmissibility |
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Window period
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period between the end of detection of HBsAg and the beginning of detection of HBsAb
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