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28 Cards in this Set
- Front
- Back
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What are the 4 types of hypersensitivity? Give a 3 word descript of each
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Type 1- immediate hypersensitivty
Type 2 - Cytotoxic Ab Type 3 - Immune Complex Type 4 - delayed type |
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Type 1 hypersensitivity is Cell mediated? or Serum mediated?
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Serum (Antibody)
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In Type 1 hypersensitivity
1. Ab? 2. Cells? |
1 - IgE
2 - Mast, basophil |
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Whta is the receptor for IgE on a Mast cell?
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FCepslionR1
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What are the 2 types of mast cells involved in Type 1 hypersensitivity, when are each activated?
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CT - thru intravenous or subcutaneous
Mucosal - inhalation or ingestion |
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Of the following, which 4 are primary and which 4 are secondary mediators in Type 1 hypersensitivity:
Histamine, Bradykinin, Cytokines, Serotonin, Proteases, Chemotactic factors, Prostaglandings, Leukotrienes |
primary - SPCH - sero, protease, chemotactic factors, histamine
secondary - CBLP cytokines, bradykinin, Leukotrienes, Prostaglandinds |
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What are 2 diseasesof skin that are Type 1?
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Uriticaria and Angiodema
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What is a disease of upper resp tract that is type 1?
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Allergic RHINITIS
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What type of hypersensitivity is a food allergy?
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Type 1
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What type of hyp. is allergic asthma?
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Type 1 lower resp.
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What is a SYSTEMIC Type 1 hypersensitivity reaction?
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Anaphylaxis
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What is OMALIZUMAB?
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Helps to treat Type 1 hypersensitivity by binding to IgE, preventing it from binding to mast cells' FCeR1 receptor
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What is the defining example of Type 2 hypersensitivity?
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miss-matched donor-recepient blood transfusion
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What type of Ab's are involved in Type 2 hypersensitivity?
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IgG and IgM
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What is Autoimmune Hemolitic Anemia?
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Patien produces Abs to OWN RBC's
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What is Hashimoto Thyroiditis
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Autoreactive Ab to Thyroid proteins, Type 2 hypersens
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What is Goodpasture syndrome
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IgG reactsw/ basement membrane - distruction of kidney type 2
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What type of hypersensitivity reaction is Rh
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Type 2
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What type of Ag's are involved in Type 3 hypersns reations?
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Soluble Ags
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What are the 2 mechanisms of type 3 hypersensitivity
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Mech A - Ag reacts w/ IgG, IgG binds mast cell, local inflammation etc. results
Mech B - Ig-Ag complex in blood, binds neutrophils in blood |
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What type of Reaction is Arthus? symptoms?
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Cutaneous Lesion Type 3
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What type of reaction is rheumatoid arthritis?
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Type 3 - attack joints
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What type of reaction is Lupus erythromatosus?
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Type 3 (AND TYPE 2)- attack DNA/Histones
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What type of rxn is serum sickness?
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Type 3 - anti serum/Ab from animals or peniclin
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What type of reaction is Farmer's Lung?
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Hypersensitivity pneumonitits, (like asthma) type 3
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What is unique about Type 4 hypersensitvity?
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It is CELL MEDIATED - T, Dendritic, macrophages
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What type of hypersensitivity is Contact hypersens? (Give examples
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poison ivy, haptens. it is a Type 4
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What type of hypersens results from mycobacteria or insect venom?
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Type 4
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