Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
40 Cards in this Set
- Front
- Back
What are the arboviruses?
|
Flaviviridae, Togaviridae, Reoviridae (arbo indicates mode of transmission, not family)
|
|
Jungle cycle vs urban cycle?
|
Jungle: insect-monkey-insect
Urban: insect-man-insect |
|
What are the positive RNAs
|
Call Pico and Flo To Come Rightaway
Calicivirus, Picornavirus, Flavivirus, Togavirus, Coronavirus, Retrovirus |
|
What are the only naked RNA viruses?
|
C Porn Repeatedly
Calicivirus Picornavirus Reovirus |
|
Which are the segmented RNA?
|
ROBA:
Reovirus Orthomyxa Bunya Arena |
|
Vector for Flaviviridae?
|
Mosquito or tick
|
|
Virion structure of Flaviviridae?
|
+ssRNA, enveloped
|
|
What diseases do Flaviviridae cause?
|
West Nile, Yellow Fever, Dengue Fever, St. Louis Encephalitis, HCV!!
|
|
Most cases of WNV presents how?
|
inapparent except for mild feve and over in a week.
Serious cases result in encephalitis |
|
WNV Hosts?
|
Birds
|
|
Reservoir for SLE?
|
Birds, but SLE virus is not a pathogen in birds or horses.
|
|
Transmission of SLE?
|
mosquito
|
|
Encephalitis, aseptic meningitis, renal failure around Ohio and Missisippi River basins
|
SLE
|
|
Moquito bite in Tropical Africa and South America. What appears in my liver?
|
councilman bodies
|
|
Pathogenesis of Yellow fever?
|
1-3 days incubation, then
first stage: N/V with hemorrhage and hypothermia second: venous stasis, hemorrhage, kidney probs |
|
Theiler vaccine is what?
|
live, attenuated, for Yellow fever virus
|
|
Most common arthropod borne disease?
|
Dengue virus (Daaang its common but without significant portality)
|
|
Geographic distribution of Dengue virus?
|
everywhere with both a jungle and urban cycle
|
|
I get a biphasic fever with loe WBC and platelet count. What do I have and how many serotypes?
|
dengue fever caused by one of four dengue viral serotypes
|
|
What is the pathogenesis of dengue hemorrhagic fever?
|
When a subsequent infection of the dengue virus of a different serotype is not neutralized by prior ABs and instead can infect macrophages via Fc and complement receptors.
|
|
Hosts of yellow fever?
|
Due to both jungle and urban cycles, the hosts for this virus are both monkey and man
|
|
DHF occurs most often in who?
|
children less than 12 yrs old
|
|
diagnosis of flaviviridae?
|
isolation from blood, not so much CF or HAI due to cross reacting Abs between flaviviridae
|
|
Flaviviridae found in USSR?
|
tick-borne encephalitis
|
|
Flaviviridae found in asia?
|
japanese encephalitis
|
|
Togaviridae causes what diseases?
|
the alphaviruses cause encephalitis; rubivirus causes german measles
|
|
Pathogenesis of alphaviridae-mediated encephalitis?
|
a 2-day systemic malaise then a potentially fatal encephalitic phase
|
|
Which alphaviridae encephalitis is most severe?
|
EEE is EEEK! 70% death
Wee is little (<10% |
|
Epidemiology of EEE?
|
least common usually EEEE and south USA
|
|
epidemiology of WEE?
|
around 200 cases a year WEE is WEEst of the missippi
|
|
most common togaviridae encephalitis?
|
VEE gets thousands per year in south and central america (non us)
|
|
Diagnosis of togaviridae encephalitidies?
|
viral recovery in blood, brain, or csf; also sera to ID by antibody
|
|
What Togavirus is not spread via arthropods?
|
Rubivirus (Rubella virus)
|
|
What is transplacental infection of Rubivirus dependent upon?
|
if mother is in viremic phase and dependent of gestational age (determines transmission % and severity of disease)
|
|
Clinical manifestations of babies with rubella?
|
blueberry muffin babies (TTP)
salt and pepper (cataract retinopathy) celery stalking (osteitis) |
|
Most common cause of congenital sensorineural deafness before vaccinations existed?
|
congenital rubella
|
|
Most common arboviral infection in US: virion family and structure?
|
this is Orbivirus (mountain fever aka colorado tick fever); belongs to Reovirus which is dsRNA naked, segmented
|
|
What does colorado tick fever present as?
|
kinda like R. Rickettsia; biphasic fever and 10% have a rash
|
|
Rotavirus genome?
|
11 dsRNA!
|
|
disease caused by rotavirus?
|
Gastroenteritis that resolves in 2-7 days ; this is significant in infants and adult IC
|