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18 Cards in this Set
- Front
- Back
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What is the form of cocciodies immitus found in the infected individual? Environmental form that infects hosts?
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Spherules with endospores.
Arthroconidium |
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What are the 2 antigens that can be immunoassayed to test for coccoides? What is the limitation of this test?
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Coccidoidin and Spherulin.
Antibodies will cross react with Histoplasmosis and Pacoccidioidies. |
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What does a Coccidioides infection present like?
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If pulmonary it looks like the flu: fever, lymphadenopathy, malaise, cough
May develop into diffuse pneumonia |
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What is erythema nodosum and why is it a good sign? When does it usually develop?
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Delayed (cell-mediated) hypersensitivity to fungal
antigens. Due to disseminated infection Tender red nodules Tells you normal immune response is occuring and pt will recover 1mo after infection |
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How is Coccidiodes transmitted?
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Via inhalation of ATHROCONIDIA
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Do cocci spherules stain PAS positive?
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Yes
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Does ethniciy predispose you to cocci?
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Yes. Asians, Af. Americans, Am. indians, and mexicans
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What are the 2 morphologies of Histoplasmosis Capsulatum? Which is the infective form?
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Macroconidia and Microconidia
Microconidia |
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How do macrophages help a H. Capsulatum infection get worse
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They help them to disseminate
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How is C. Immitus diagnosed
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Sample(sputum, pus, CSF) treated with 10% KOH and PAS stained for Spherule presence
IgM and IgG to coccdiodin or spherulin can confirm also |
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What is a common name for a coccidiodies immitus infection? What is the geographic location where most found?
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Valley Fever, Southwest
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Is C. immitus Dimorphic?
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Yes
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What are 2 diagnostic signs of H. Capsulatum infection?
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Microscopic: Intracellular yeast formation. Budding confirms its yeast
Immunoassay that detects histoplasmin |
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What is a virulence factor produced by H. Capsulatum? What does it do?
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Urease. Inhibits phagocytic killing
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How fast to H. Capsulatum grow?
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Very slow. 12 wks
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How is H. Capsulatum transmitted?
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MICROCONIDIA are inhaled
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What is the presentation of a person with pulmonary H. Capsulatum infection?
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prostrating flu-like illness, marked w/ fever, malaise, & a persistent cough
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What is our defense against H. Capsulatum?
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PMNs with fungacytic activity and T-cell mediated immunity
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