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10 Cards in this Set
- Front
- Back
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whats duchenne muscular dystrophy |
-genetic condition that affects muscles and causes weakness. progressive |
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epidemiology of DMD |
- starts in early childhood esp. around 3YO -mainly affects boys only |
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eatiology/pathopysiology of DMD |
genetic defect resulting in defective protein in muscle fibres called dystrophin. lack of dystrophin --> no calcium enterting muscle |
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signs and symptoms of DMD |
- weakness in proximal muscles , starting in lower extremeties. fine movements less affected ( fingers etc..) -difficulty walking, running, climbing stairs -use of hands to get up -delayed development -learning disability -dilated cardiomyopathy |
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investigations and diagnosis |
- symptoms -CK- very high levels -muscle biopsy -genetic test |
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what is ankylosing spondylitis ( 1B) |
-chronic seronegative spondyloarthropathy involving axial skeleton -commonly presents before age of 30 |
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symptoms & signs of ankylosing S |
symptoms: - worsening back pain (initially in the lumbosacral region) -morning stiffness |
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What spinal x-ray changes might you see in ankylising spondylitis |
* Squaring of the vertebral bodies
* Vertebral body fusion * Ossification of spinal ligaments |
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acute dystonia |
- neurological movement disorder associated w/ muscle contractions result in twisting and repetitive movements or abnormal posture. can be induced by dopamine receptor blockers i.e haloperidol |
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What is Lambert-Eaton Myasthenic Syndrome (LEMS) |
-Autoimmune disease -Affects neuromuscular Junction -immune system attacks ca+ channels which cause release of acetylcholine which causes muscle contraction ➡️muscles do not contract ➡️causes weakness -associated with small cell cancer |
